OPEN-ANGLE GLAUCOMA

This trial tests three different laser trabeculoplasty methods—selective, micropulse, and pattern—in people with open-angle glaucoma who are already using eye drops to lower pressure. Each participant receives one 360-degree laser session, and the main goal is to see if the metho…

This study looks at the long-term safety and effectiveness of bimatoprost SR, a tiny implant placed in the eye that slowly releases medication to lower eye pressure. It includes people with open-angle glaucoma or ocular hypertension who have already used bimatoprost SR in earlier…

This study tested a new implant called PER-001 placed inside the eye to treat open-angle glaucoma. The trial included 33 adults and checked for safety and how well it controlled eye pressure. The implant is designed to release medication over time, potentially reducing the need f…

This study compared two small eye implants, Hydrus and iStent, placed during cataract surgery to help lower eye pressure in people with open-angle glaucoma. 65 patients were followed long-term to see which device worked better and was safer. The goal was to reduce the need for gl…

This study tested a new eye drop called Reformulated PG324 to see how well it lowers eye pressure in people with open-angle glaucoma or high eye pressure. About 489 adults took part. The goal was to measure the drop's safety and effectiveness in controlling eye pressure, which is…

This study tested a gel stent implant for open-angle glaucoma, a leading cause of blindness. 74 adults aged 45+ received the implant and were followed for 12 months. The goal was to safely lower eye pressure and reduce the need for glaucoma medications.

This study tested a small device called the Hydrus Microstent in 217 adults with open-angle glaucoma that was not well controlled with other treatments. The goal was to see if the implant could safely lower eye pressure. After 12 months, many patients had a significant drop in ey…

This study tested two different laser treatment locations for open-angle glaucoma: one targeting the nasal side of the eye and one targeting the inferior side. 13 patients received the laser procedure to see which location better lowers eye pressure. The goal is to find the most …

This completed Phase 2 trial tested two strengths of a new eye drop called T4090 against the existing drug Rhopressa in 161 adults with open-angle glaucoma or ocular hypertension. The goal was to see which better lowers eye pressure over 7 weeks. Participants used one drop daily …

This early-stage study tested a tiny implant placed inside the eye that slowly releases medication to lower eye pressure in people with mild-to-moderate open-angle glaucoma. The goal was to find a dose that works well with few side effects. 37 adults took part, and researchers mo…

This phase 2 trial tested two new eye drop formulas, AR-17043 and PG043, in 426 people with open-angle glaucoma or ocular hypertension. The goal was to see if they safely lower eye pressure better than existing drops. Participants received different doses of the study drops or st…

This study tested whether a daily oral solution containing citicoline and nicotinamide (Kron) could improve eye function in 30 people with open-angle glaucoma. Participants took the supplement and had their retinal and visual cortex activity measured. The goal was to see if the c…

This phase 3 trial tested whether a new eye drop called NCX 470 can lower eye pressure better than the standard drop latanoprost in people with open-angle glaucoma or ocular hypertension. About 696 participants used one drop in each eye every evening for up to 12 months. The stud…

This study tested a device that combines a bimatoprost implant with a special intraocular lens to treat both cataracts and glaucoma or high eye pressure. Twenty-four participants received the implant during cataract surgery. The main goals were to see if it lowers eye pressure an…

This study compares two visual field tests used to monitor glaucoma: the current standard Humphrey Visual Field Analyzer and the newer iCare COMPASS. About 28 people with glaucoma or related eye conditions will take both tests in the same visit, with the order alternating between…

This study looked at how the eye produces and drains fluid to understand why glaucoma medications lower eye pressure more in some people than others. Researchers measured eye fluid production, drainage, and pressure in 59 adults with glaucoma or high eye pressure before and after…

This completed study tested NCX 470 eye drops in 18 healthy adults to see how they change fluid dynamics inside the eye. Participants received either the active drop or a placebo for 8 days. The goal was to measure fluid production, drainage, and pressure. Results will help resea…