NON-SMALL CELL LUNG CARCINOMA

This study tests a vaccine made from lung cancer cells, combined with an immune-boosting drug (N-803), in people who have had surgery for non-small cell lung cancer and whose tumors are PD-L1 negative. The goal is to see if the vaccine can train the immune system to recognize and…

This study tests a new drug called JDQ443 combined with other therapies in people with advanced solid tumors that have a specific genetic change called KRAS G12C. The goal is to find safe doses and see if the combinations can shrink or control the cancer. About 74 adults with lun…

This early-phase study tests a combination of two drugs—trastuzumab deruxtecan and pembrolizumab—in people with advanced breast or non-small cell lung cancer that has spread. The goal is to find the safest dose and see if the combo shrinks tumors. About 115 adults with HER2-posit…

This early-stage trial tests a vaccine (p53MVA) plus the immunotherapy drug pembrolizumab in 11 adults with advanced solid tumors that have not responded to other treatments. The vaccine trains the immune system to target cancer cells with a faulty p53 gene, while pembrolizumab h…

This study tests whether adding high-dose vitamin C (ascorbate) to the usual treatment of radiation and chemotherapy can help control non-small cell lung cancer. About 43 participants will receive the vitamin C alongside their standard therapy. The goal is to see if the combinati…

This study tests an experimental drug called AZD2936 (rilvegostomig) in people with advanced or metastatic non-small cell lung cancer (NSCLC) that cannot be removed by surgery. The drug is a bispecific antibody designed to block two immune checkpoints (TIGIT and PD-1) to help the…

This study tests an online program designed to help women with lung cancer feel more supported and less distressed during treatment. The program uses techniques like mindfulness and emotional processing to improve social well-being. About 70 women with stage I-IV non-small cell l…

This study tests whether adding acupuncture to standard immunotherapy and chemotherapy can help people with advanced non-small cell lung cancer. About 60 participants will receive either real or sham acupuncture alongside their first four treatment cycles. The goal is to see if a…

This study collects blood samples from 102 people with non-small cell lung cancer, colorectal cancer, or pancreatic cancer to track cancer-related DNA changes over the course of their standard treatment. Researchers aim to see if these blood-based markers can help predict tumor r…