NEOPLASM METASTASIS

This early-stage study tests a new daily pill, zongertinib, in adults with advanced solid tumors (including lung cancer) that have HER2 gene changes and haven't responded to prior treatments. The first part finds the best dose; the second part checks if the drug shrinks tumors. P…

This study tests an experimental drug called 9-ING-41, which blocks a protein (GSK-3β) that helps cancers grow. It is given alone or with chemotherapy to 350 adults with advanced or hard-to-treat cancers like pancreatic, breast, lung, or bone cancer. The goal is to see if the dru…

This early-stage study tests an experimental drug called MK-6837, given alone or with another drug (pembrolizumab), in people with advanced solid tumors that have stopped responding to standard treatments. The main goals are to check safety, find the right dose, and see if the dr…

This study tests whether adding abemaciclib to fulvestrant can help people with a certain type of advanced breast cancer (HR+, HER2-) that has gotten worse after initial treatment with a CDK4/6 inhibitor and hormone therapy. About 368 participants will receive either the drug com…

This study tests whether adding the drug abemaciclib to standard chemotherapy can help people with Ewing's sarcoma that has returned or not responded to treatment. About 46 children and young adults will participate. The goal is to see if the combination slows tumor growth and im…

This study provides continued access to trastuzumab emtansine (a targeted cancer drug) for patients with metastatic cancer who were already benefiting from it in a previous trial. About 720 participants will receive the drug alone or with other cancer treatments, and researchers …

This study tests if using focused ultrasound (MR-HIFU) alone or with standard radiation can better relieve bone pain caused by cancer that has spread to the bones. About 216 adults with painful bone metastases will receive either ultrasound, ultrasound plus radiation, or radiatio…