NEOPLASM METASTASIS

This early-stage trial is testing a new oral drug called zongertinib for people with advanced solid tumors, mainly non-small cell lung cancer, that have specific changes in the HER2 gene. The first part aims to find the highest safe dose. The second part will see if the drug can …

This study is for people with a specific type of advanced breast cancer that has continued to grow despite previous hormone therapy and a targeted drug. It tests whether adding a medication called abemaciclib to standard fulvestrant therapy is better at controlling the cancer tha…

This study is testing whether adding a drug called abemaciclib to standard chemotherapy (irinotecan and temozolomide) is better at controlling Ewing's sarcoma that has returned or stopped responding to treatment. It involves about 46 children and young adults. The main goal is to…

This is the first human study of a new cancer drug called MK-6837. Researchers are testing it alone and combined with an existing immunotherapy (pembrolizumab) in 168 people with advanced solid tumors that have stopped responding to standard treatments. The main goals are to find…

This study allows patients with metastatic breast cancer who were benefiting from the drug trastuzumab emtansine in previous trials to continue receiving it. The main goal is to monitor long-term safety and side effects while patients keep getting treatment. The study includes 72…

This study is testing whether a non-surgical treatment using focused sound waves (MR-HIFU), either alone or combined with standard radiation therapy, can relieve pain from cancer that has spread to the bones faster and better than radiation alone. It involves about 216 adult pati…