NASH - NONALCOHOLIC STEATOHEPATITIS

This study tests whether semaglutide (a once-daily pill) works better than sitagliptin (another diabetes drug) at controlling blood sugar and body weight in people who have had a liver transplant and have poorly controlled diabetes. About 58 adults who are at least 3 months post-…

This study looks at whether a monitored ketogenic (low-carb, high-fat) diet is safe and effective for weight loss in obese adults with NASH cirrhosis, a serious liver condition. About 40 participants will either follow the ketogenic diet or standard dietary advice for 16 weeks. R…

This study tests whether a natural compound called tocotrienol (a form of vitamin E) can slow the worsening of end-stage liver disease in 70 adults with cirrhosis. Participants take either tocotrienol capsules or a placebo twice daily for 3 years. The goal is to see if the treatm…

This study tests if atorvastatin (Lipitor), a widely used cholesterol medicine, can safely improve liver damage in people with NASH, a serious fatty liver disease. About 70 adults with confirmed NASH and liver scarring will receive either the drug or a placebo for several months.…

This study tests a new medicine called HM15211 (Efocipegtrutide) in 215 adults with NASH, a serious fatty liver disease with scarring. Participants receive either the drug or a placebo for 12 months. The main goal is to see if the drug can clear the liver inflammation without mak…

This large Phase 3 study is testing whether the drug lanifibranor can help adults with NASH, a serious form of fatty liver disease that causes inflammation and scarring. The trial involves 1,000 participants who will receive either the active drug or a placebo for 72 weeks to see…

This study is collecting health and genetic information from 120,000 people with chronic diseases like pancreatitis, inflammatory bowel disease, diabetes, and arthritis. Researchers want to understand how genes, lifestyle, and other factors affect disease progression and quality …

This study follows 400 adults with HIV to learn how nonalcoholic fatty liver disease (NAFLD) develops and progresses in this group. Researchers use a non-invasive ultrasound-like scan to measure liver fat and stiffness over one year. The goal is to fill major knowledge gaps, sinc…

This study tests a new, non-invasive MRI technique that measures liver stiffness and viscosity to identify NASH patients at higher risk for liver cancer. About 35 adults with NASH and early-stage liver scarring will undergo a longer MRI scan (40 minutes vs. 25). The goal is to se…

This study looks at how the liver burns fat and produces sugar in people with NASH (a serious fatty liver disease) who are planning to have weight-loss surgery. Researchers will use special scans to measure these liver functions before and after surgery. The goal is to understand…