Natural vitamin e pill may delay liver transplant in cirrhosis patients
NCT ID NCT02581085
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 2 trial tests whether a natural vitamin E supplement called tocotrienol can slow the worsening of end-stage liver disease. Seventy adults with stable but advanced liver disease (MELD score 8–17) will take either tocotrienol or a placebo twice daily for three years. The main goal is to see if the supplement prevents a rise in the MELD score, which measures liver function and predicts transplant need.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Tocotrienol (a natural vitamin E supplement)
- What this could lead to
- If it works, this could provide a simple, safe supplement to slow liver damage and delay the need for a transplant in people with end-stage liver disease.
- What could go wrong
- This is a small, early-phase trial (70 people) testing a supplement against a placebo. Previous results need confirmation, and the supplement may not slow disease progression or prevent serious complications.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
IU Health Unviersity Hospital
Indianapolis, Indiana, 46202, United States
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