NAFLD

This study tests whether empagliflozin, a diabetes drug, can prevent liver scarring (fibrosis) from getting worse in people with chronic hepatitis B. About 106 adults with moderate to advanced liver scarring will take either the drug or a placebo daily for three years. The goal i…

This study follows 200 people with nonalcoholic fatty liver disease (NAFLD) who get a temporary intragastric balloon to help with weight loss. Researchers will track changes in weight, liver enzymes, blood sugar, and liver stiffness for at least one year. The goal is to see if th…

This study compares two diabetes pills—semaglutide (the drug in Ozempic) and sitagliptin—in 58 adults who have had a liver transplant and have poorly controlled diabetes. Participants take one pill daily for about 6 months. The goal is to see which drug better lowers blood sugar …

This study looks at whether a very low-calorie diet (800-960 calories per day) can reduce fat and scarring in the liver for people with obesity and non-alcoholic fatty liver disease (NAFLD). Twenty participants will follow either the low-calorie diet or a standard lower-calorie d…

This study tests an experimental drug called efinopegdutide in 80 adults with liver scarring (cirrhosis) caused by metabolic dysfunction-associated steatohepatitis (MASH), a type of fatty liver disease. The goal is to see if the drug can reduce liver fat, inflammation, and scarri…

This study was designed to test a new thermo-acoustic imaging device that may help diagnose fatty liver disease without invasive procedures. It would have compared the device's accuracy to standard MRI scans in adults aged 18-70 with known or suspected fatty liver. However, the s…

This study tests a new portable device called LiverScope that uses simplified MRI technology to measure fat in the liver. Researchers will compare it to standard MRI and FibroScan exams in 50 adults with known or suspected fatty liver disease (NAFLD). The goal is to see if LiverS…

This study looks at how often fatty liver disease occurs in people living with HIV. Researchers will measure liver fat in 1,250 adults with HIV who are on stable treatment. The goal is to understand the true scale of this liver condition in this group, which has been largely over…

This study aims to find out how many people with type 2 diabetes also have non-alcoholic fatty liver disease (NAFLD). Researchers will use a special ultrasound scan (FibroScan) to check the liver health of 385 adults with type 2 diabetes. The study does not test any new treatment…

This study follows 400 adults with HIV to learn how nonalcoholic fatty liver disease (NAFLD) progresses in this group. Researchers will use a non-invasive scan to measure liver fat and stiffness at the start and after one year. The goal is to fill major knowledge gaps, since past…