METASTATIC COLORECTAL ADENOCARCINOMA
Clinical trials for METASTATIC COLORECTAL ADENOCARCINOMA explained in plain language.
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New pill targets stubborn colorectal cancer mutation
Disease control Not yet recruitingThis study tests an experimental pill called VS-7375, designed to block a specific cancer-driving protein (KRAS G12D). The trial includes people with metastatic colorectal cancer that has this mutation. Some participants receive VS-7375 alone, others get it combined with an antib…
Matched conditions: METASTATIC COLORECTAL ADENOCARCINOMA
Phase: PHASE2 • Sponsor: Verastem, Inc. • Aim: Disease control
Last updated Jun 27, 2026 14:01 UTC
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Could a diabetes drug boost chemo for tough cancers?
Disease control Not yet recruitingThis early-phase trial will test whether adding semaglutide (a GLP-1 drug used for diabetes and weight loss) to standard chemotherapy is safe and tolerable for people with metastatic pancreatic, colorectal, or liver cancer. About 30 participants will receive weekly semaglutide in…
Matched conditions: METASTATIC COLORECTAL ADENOCARCINOMA
Phase: EARLY_PHASE1 • Sponsor: University of Arizona • Aim: Disease control
Last updated Jun 27, 2026 13:04 UTC
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New combo therapy targets Hard-to-Treat cancers
Disease control Not yet recruitingThis early-phase study tests a new drug combination (L19IL2 plus ruxolitinib) in people with advanced kidney, pancreatic, or colorectal cancers that have stopped responding to standard treatments. The main goals are to find a safe dose and check for side effects. About 96 partici…
Matched conditions: METASTATIC COLORECTAL ADENOCARCINOMA
Phase: PHASE1 • Sponsor: Philogen S.p.A. • Aim: Disease control
Last updated Jun 27, 2026 12:28 UTC
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New combo therapy aims to fight advanced colorectal cancer
Disease control Not yet recruitingThis phase II trial tests whether a special radiotherapy regimen followed by targeted therapy and immunotherapy can shrink tumors in people with advanced colorectal cancer that has not responded to prior treatments. About 33 participants will receive the treatment and be monitore…
Matched conditions: METASTATIC COLORECTAL ADENOCARCINOMA
Phase: PHASE2 • Sponsor: Daping Hospital and the Research Institute of Surgery of the Third Military Medical University • Aim: Disease control
Last updated Jun 27, 2026 11:00 UTC
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New hope for advanced colon cancer: drug duo targets tumors
Disease control Not yet recruitingThis study tests a new drug combination (SHR-1811 plus bevacizumab) as a second-line treatment for people with metastatic colorectal cancer that has worsened after initial therapy. About 80 adults aged 18-75 will participate. The goal is to see if the combo shrinks tumors and del…
Matched conditions: METASTATIC COLORECTAL ADENOCARCINOMA
Phase: PHASE2 • Sponsor: Peking Union Medical College Hospital • Aim: Disease control
Last updated Jun 27, 2026 08:12 UTC
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New drug combo aims to fight colorectal cancer when standard chemo fails
Disease control Not yet recruitingThis Phase 2 trial tests whether a new drug combination (fruquintinib plus trifluridine/tipiracil) works better than a standard combo (bevacizumab plus trifluridine/tipiracil) for people with advanced colorectal cancer that has not responded to standard chemotherapy. About 292 ad…
Matched conditions: METASTATIC COLORECTAL ADENOCARCINOMA
Phase: PHASE2 • Sponsor: Cancer Institute and Hospital, Chinese Academy of Medical Sciences • Aim: Disease control
Last updated Jun 27, 2026 08:12 UTC
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Can lower chemo doses help older cancer patients?
Knowledge-focused Not yet recruitingThis study looks at medical records of 51 patients aged 70 and older with metastatic colorectal cancer. Researchers want to see if using lower doses of chemotherapy along with full-dose targeted therapy can reduce serious side effects like low white blood cell counts and severe d…
Matched conditions: METASTATIC COLORECTAL ADENOCARCINOMA
Sponsor: Matteo Clavarezza • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:02 UTC