LUNG TRANSPLANT

This study tests whether adding tocilizumab to standard anti-rejection drugs can prevent chronic lung allograft dysfunction (CLAD) in 350 lung transplant recipients. Participants receive either tocilizumab or a placebo for 20 weeks, and researchers track CLAD, re-transplant listi…

This study tests whether the drug belumosudil can prevent chronic lung allograft dysfunction (CLAD) in people who have had a lung transplant and show signs of rejection or inflammation on a biopsy. About 234 participants will receive either belumosudil or a placebo for 52 weeks, …

This study compares two ways to perform double lung transplants: one without a heart-lung machine (off-pump) and one using a machine called VA ECMO. The goal is to see which method leads to fewer lung complications after surgery. About 228 people receiving double lung transplants…

This early-stage study tests a new way to use a heart-lung machine (ECMO) in 4 people waiting for a lung transplant who also have heart failure from high blood pressure in the lungs. The goal is to see if this approach can keep them alive and stable until they receive a transplan…

This study tests whether health coaching before a lung transplant can improve emotional health and self-management. 230 adults waiting for a lung transplant will receive up to 12 coaching phone calls over 12-16 weeks, or standard care. Researchers will measure changes in quality …

This study tests whether 12 sessions of Latin dance can improve wellbeing in people who have had a lung transplant. Researchers will measure changes in anxiety, depression, fear of movement, balance, and breathing. The study aims to enroll 52 participants who are already out of t…

This study aims to understand why some people who get a lung transplant develop rejection while others do not. Researchers will follow 100 adults aged 18 to 75 who have progressive lung disease or have had or may get a lung transplant. Participants will have regular check-ups, bl…

This study is building a large collection of blood, tissue, and fluid samples from 7,000 people with lung cancer, other chest diseases, or lung transplants. The goal is to help researchers learn more about what causes these diseases, how to find them early, and how to treat them …

This registry will collect short- and long-term outcome data from up to 10,000 lung transplant recipients whose donor lungs were preserved using the OCS Lung device. The goal is to see how well the device performs in everyday medical practice after FDA approval. Researchers will …