Can a rheumatoid arthritis drug save lung transplants?
NCT ID NCT06033196
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether adding tocilizumab to standard anti-rejection drugs can prevent chronic lung allograft dysfunction (CLAD) in 350 lung transplant recipients. Participants receive either tocilizumab or a placebo for 20 weeks, and researchers track CLAD, re-transplant listing, or death over 36 months. The goal is to see if tocilizumab improves long-term transplant success.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Tocilizumab (also known as Actemra)
What this could lead to
If it works, this could reduce the risk of chronic lung rejection and improve survival after lung transplant.
What could go wrong
This is a phase 2 trial, so results are still uncertain. Tocilizumab may cause side effects like infections, and the benefit over standard care is not yet proven.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Barnes Jewish Hospital/ Washington University SOM (Site #: 71191)
RECRUITINGSt Louis, Missouri, 63110, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Boston Children's Hospital and Harvard Medical School (Site #: 71001)
WITHDRAWNBoston, Massachusetts, 02215, United States
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Cedars Sinai Medical Center (Site #: 71146)
RECRUITINGBeverly Hills, California, 90211, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Cleveland Clinic (Site #: 71101)
RECRUITINGCleveland, Ohio, 44195, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Columbia University Medical Center (Site #: 71113)
RECRUITINGNew York, New York, 10032, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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David Geffen School of Medicine at UCLA (Site #: 71123)
RECRUITINGLos Angeles, California, 90095, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Duke University Medical Center (Site #: 71139)
RECRUITINGDurham, North Carolina, 27710, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Emory University (Site #: 71103)
NOT_YET_RECRUITINGAtlanta, Georgia, 55905, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Houston Methodist Hospital (Site #: 71120)
WITHDRAWNHouston, Texas, 77030, United States
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Massachusetts General Hospital (Site #: 71107)
RECRUITINGBoston, Massachusetts, 02114, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Mayo Clinic Rochester (Site #: 71160)
NOT_YET_RECRUITINGRochester, Minnesota, 55905, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Ohio State University Medical Center (Site #: 71196)
RECRUITINGColumbus, Ohio, 43210, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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St. Joseph's Hospital and Medical Center (Site #: 71192)
RECRUITINGPhoenix, Arizona, 85013, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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St. Louis Children's Hospital of Washington University (Site #: 71006)
WITHDRAWNSt Louis, Missouri, 63110, United States
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Temple University (Site #: 71197)
NOT_YET_RECRUITINGPhiladelphia, Pennsylvania, 19140, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Florida Shands Hospital (Site #: 71131)
NOT_YET_RECRUITINGGainesville, Florida, 32610, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Maryland Medical Center (Site #: 71138)
WITHDRAWNBaltimore, Maryland, 21201, United States
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University of Texas Health Science at San Antonio (Site #: 71198)
NOT_YET_RECRUITINGSan Antonio, Texas, 78229, United States
Contact Email: •••••@•••••
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University of Texas Southwestern (Site #: 71187)
RECRUITINGDallas, Texas, 75390, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Utah Medical Center (Site #: 71126)
RECRUITINGSalt Lake City, Utah, 84132, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Vanderbilt University (Site #: 71174)
NOT_YET_RECRUITINGNashville, Tennessee, 37232-0393, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••