LIVER TRANSPLANT

This study tests a vaccine against cytomegalovirus (CMV) given to people before they receive a liver transplant. The goal is to see if the vaccine can lower the amount of antiviral medicine needed after the transplant. About 416 participants who are CMV-negative and waiting for a…

This study tests whether a combination of two drugs, atezolizumab and bevacizumab, is safe for liver transplant patients whose liver cancer has returned and cannot be treated with surgery or local therapies. About 50 participants will receive the drug combination along with a sta…

This study tests whether liver transplant recipients can safely stop taking one anti-rejection medicine (tacrolimus) and use only everolimus to protect their kidneys. About 340 adults who received their first liver transplant will join. The goal is to see if this approach keeps t…

This study tests whether a special machine can restore moderately fatty donor livers so they can be safely transplanted. About 200 adults awaiting a liver transplant will receive a machine-treated liver. If successful, this approach could expand the number of usable donor organs …

This study tests a drug called cabozantinib in 20 adults whose liver cancer came back after a liver transplant. The goal is to see if the drug can control the cancer and slow its growth. Participants take the drug until it stops working or side effects become too severe.

This study tests whether two drugs, everolimus and epoetin, can help liver transplant patients safely stop taking their standard anti-rejection medication (tacrolimus). About 20 adults who are 1-10 years post-transplant and stable on tacrolimus will switch to everolimus, receive …

This study tests if a doctor-led counseling program, plus two smartphone apps, can help older adults (60+) who have had a liver or kidney transplant eat better and be more active. Sixty participants will first get lifestyle advice, then use the apps for 12 weeks. The main goal is…

This study tests a small, disposable device placed on the ear that stimulates nerves to help manage pain after open abdominal or pelvic surgery. The goal is to see if it reduces the amount of opioid painkillers patients need during their hospital stay. About 286 adults having can…

This study is testing a digital tool to help young people (ages 14-20) who have had or are waiting for a liver transplant as they move from pediatric to adult medical care. The tool is designed to help patients and their families manage treatment remotely and improve medication a…

This study looks at the long-term health of children (16 and older) whose mothers had a solid organ transplant before pregnancy. Researchers want to see if these children have higher risks for heart or kidney problems, possibly due to the mother's anti-rejection medications. Abou…

This study follows 40 liver transplant patients after they leave the hospital, using a continuous glucose monitor to track their blood sugar levels. The goal is to see how well blood sugar is controlled and whether it affects transplant outcomes like wound healing or complication…