KNEE ARTHRITIS
Clinical trials for KNEE ARTHRITIS explained in plain language.
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Knee replacement showdown: fixed vs. mobile bearing – which is better?
Disease control CompletedThis study compared two types of total knee replacements in 160 patients with medial knee arthritis. One group received a fixed-bearing implant, the other a mobile-bearing implant. Researchers measured knee function and X-ray results to see if one design leads to better outcomes.
Matched conditions: KNEE ARTHRITIS
Phase: NA • Sponsor: Hospices Civils de Lyon • Aim: Disease control
Last updated Jun 27, 2026 12:34 UTC
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Surgeons can do nerve blocks just as well as anesthesiologists for knee replacement pain
Symptom relief CompletedThis study tested whether surgeons can give a numbing shot (adductor canal block) during knee replacement surgery as effectively as an anesthesiologist does before surgery. 200 adults with knee osteoarthritis having same-day discharge were randomly assigned to one of the two meth…
Matched conditions: KNEE ARTHRITIS
Phase: NA • Sponsor: Ottawa Hospital Research Institute • Aim: Symptom relief
Last updated Jun 27, 2026 12:37 UTC
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Knee surgery pain relief: which additive works best?
Symptom relief CompletedThis study tested whether adding dexamethasone or dexmedetomidine to a standard nerve block (erector spinae plane block) improves pain control after total knee replacement. 90 adults undergoing knee surgery received one of the two drugs or a placebo alongside the nerve block. Res…
Matched conditions: KNEE ARTHRITIS
Phase: PHASE4 • Sponsor: Poznan University of Medical Sciences • Aim: Symptom relief
Last updated Jun 27, 2026 12:02 UTC
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New nerve block may ease knee surgery pain without slowing you down
Symptom relief CompletedThis study tested a special nerve block called the parasartorial compartment block to see if it reduces pain after knee surgery. Sixty adults having knee surgery under spinal anesthesia received the block plus standard painkillers. Researchers measured pain scores and how much ex…
Matched conditions: KNEE ARTHRITIS
Phase: NA • Sponsor: Medipol University • Aim: Symptom relief
Last updated Jun 27, 2026 08:01 UTC
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New pain block technique may cut opioid use after knee surgery
Symptom relief CompletedThis study tested two different nerve block methods to control pain after total knee replacement surgery. Sixty older adults (ages 65-100) received either a two-level erector spinae block or an iPack with ACB block. The main goal was to see which method reduced the need for opioi…
Matched conditions: KNEE ARTHRITIS
Phase: PHASE4 • Sponsor: Poznan University of Medical Sciences • Aim: Symptom relief
Last updated Jun 27, 2026 07:59 UTC
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Could a cord tissue injection ease severe knee arthritis?
Symptom relief CompletedThis phase 2 trial tested whether a single injection of TTAX03, made from human amniotic and umbilical cord tissue, can reduce pain and improve function in people with advanced knee osteoarthritis (grades 3-4). 90 adults received either TTAX03 or a saline placebo, and researchers…
Matched conditions: KNEE ARTHRITIS
Phase: PHASE2 • Sponsor: BioTissue Holdings, Inc • Aim: Symptom relief
Last updated Jun 26, 2026 19:12 UTC
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Could a 6-Day steroid taper cut pain and opioid use after knee surgery?
Symptom relief CompletedThis study tested whether a 6-day course of oral methylprednisolone (a steroid) after total knee replacement can reduce pain, nausea, and the need for opioid painkillers. 101 adults with knee arthritis were randomly assigned to receive either the steroid taper or standard care. T…
Matched conditions: KNEE ARTHRITIS
Phase: PHASE4 • Sponsor: Emory University • Aim: Symptom relief
Last updated Jun 26, 2026 18:33 UTC