KIDNEY STONE

This trial tests a new tool called VISOR that breaks up and removes kidney stones at the same time during surgery. It includes 20 adults aged 18-80 with stones 1-3 cm. The goal is to see if it clears stones safely, with a CT scan within 24 hours and a follow-up at 4 weeks.

This study compares two long-acting diuretics (indapamide and chlorthalidone) to a standard short-acting one (hydrochlorothiazide) for preventing calcium kidney stones. About 99 adults who have had at least two kidney stones in the last 10 years will participate. The goal is to s…

This study looks at whether a healthy DASH-style diet can lower the risk of forming kidney stones. Researchers will provide all meals for one week to 48 adults with a history of kidney stones, comparing the DASH diet to a typical Western diet. The goal is to see if the DASH diet …

This study tests a flexible suction tube used during a scope procedure to remove kidney stones from the lower part of the kidney. The goal is to see if it clears more stones than standard methods. About 33 adults with lower calyx stones will take part.

This study tests a new type of ureteric stent designed to cause fewer blockages, infections, and pain than standard stents. About 50 adults who have had stents before for kidney stones or cancer will try the new stent. The goal is to see if it reduces complications and the need f…

This study compares two doses of tadalafil (2.5 mg vs 5 mg) combined with tamsulosin to reduce symptoms caused by ureteric stents placed after kidney stone removal. About 140 adults who have a stent after stone surgery will take one of the two combinations for several weeks. The …

This study compares two FDA-approved lasers (Holmium:YAG with MOSES and thulium fiber) for breaking large kidney stones during a minimally invasive surgery called mini-PCNL. About 150 adults with stones larger than 15mm will be randomly assigned to one laser, both using a suction…

This study compares two types of surgical tools used in a minimally invasive procedure to remove kidney stones. About 90 adults with stones between 10 and 25 mm will be randomly assigned to receive either a vacuum-assisted sheath or a standard sheath during surgery. The goal is t…

This early study looks at whether giving a single dose of Ketorolac (an anti-inflammatory) before placing a ureteral stent can reduce pain and discomfort after the procedure. About 36 adults with kidney stones who need a stent will be randomly assigned to receive the drug or a pl…

This study tests whether giving a diuretic (furosemide) and extra fluids during laser kidney stone surgery helps flush out tiny leftover fragments. About 374 adults will be randomly assigned to receive either the diuretic or standard care. Three months later, a CT scan will check…

This study looks at whether leaving out a ureteral stent after kidney stone surgery leads to less pain and fewer doctor visits compared to placing one. About 184 adults with kidney or ureteral stones will be randomly assigned to either get a stent or not after their procedure. Th…

This study looks at how kidney stones, insulin resistance, and inflammation are related. Researchers will compare 20 people who have had calcium kidney stones (but not diabetes) with 20 healthy people. They will measure belly fat, blood markers, and urine to understand these conn…

This study looks at whether giving surgeons live information about pressure inside the kidney during a stone-removal procedure changes the way they work. About 80 adults with large kidney stones will take part. The main goal is to see if the pressure data improves the surgeon's n…

This study looks at how two natural compounds in food—oxalate and citrate—interact in the body and affect kidney stone risk. Researchers will give potassium citrate to 24 adults (some with a history of kidney stones, some without) and measure changes in their urine over six hours…

This study looks at how two natural compounds in food—oxalate and citrate—affect the chance of forming kidney stones. Researchers will measure changes in urine after giving oxalate to 50 adults, some with a history of stones and some without. The goal is to better understand why …

This study looks at how vitamin C (ascorbic acid) turns into oxalate, a key ingredient in kidney stones. Researchers will give a special labeled vitamin C to 136 adults—both with and without kidney stones—and measure how much oxalate ends up in their urine. The goal is to underst…