HYPERALGESIA

This study tested whether a continuous drip of numbing medicine into the surgical wound for two days after back fusion surgery could reduce pain and speed recovery better than a placebo. Fifty adults having lumbar fusion for degenerative spine disease took part. The goal was to i…

This study tested a one-day educational workshop for adults with chronic non-cancer pain who take high doses of opioids. The workshop, led by a team of psychologists, pharmacists, and doctors, taught about opioid risks and a pain-management technique called Acceptance and Commitm…

This study tested whether giving ketamine during surgery and methadone after surgery can prevent a condition where opioids actually increase pain sensitivity (hyperalgesia). 113 adults having open colorectal surgery took part. The goal was to see if this approach reduces the area…

This study looked at whether two common pain tests (temporal summation and offset analgesia) give consistent results when used multiple times in healthy adults. 16 volunteers had capsaicin cream applied to their skin to create temporary sensitivity, then the tests were repeated. …

This early-phase study tested whether breathing 35% nitrous oxide (laughing gas) can reduce pain sensitivity in 20 healthy men. Researchers used mild electrical stimulation to create temporary pain and measured how well the gas worked. The goal was to understand the gas's effects…