New combo may stop opioids from making pain worse after surgery
NCT ID NCT01594047
First seen Nov 01, 2025 · Last updated May 15, 2026 · Updated 20 times
Summary
This study looked at whether giving ketamine during surgery and methadone after surgery can prevent a condition called opioid-induced hyperalgesia, where painkillers actually make you more sensitive to pain. 113 adults having open colorectal surgery took part. The goal was to see if this approach reduces the area of increased pain sensitivity around the surgical wound and lowers overall pain and opioid use.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for POST OPERATIVE PAIN are added.
By submitting, you agree to our Terms of use
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Locations
-
Fondazione IRCCS Istituto Nazionale dei Tumori
Milan, 20133, Italy
Conditions
Explore the condition pages connected to this study.