HUMAN IMMUNODEFICIENCY VIRUS (HIV)

This study is testing a combination of counseling, peer mentoring, text messages, and nicotine replacement therapy to help people with HIV quit smoking. Researchers will enroll 500 smokers living with HIV in New York City to find the most effective and affordable approach. The go…

This study tests a mutual-help group called the TLC Program for transgender adults who struggle with substance use or are recently in recovery. The program uses mindfulness and values-based skills from Acceptance and Commitment Therapy to improve mental health and reduce HIV risk…

This study compares two smartphone apps designed to help people living with HIV quit smoking. Participants will use one of the apps for about six months and also receive nicotine patches and gum. The goal is to see which app works better at helping people stay smoke-free, using b…

This study tests whether adding the drug fostemsavir to standard HIV treatment can lower the risk of heart disease in people with well-controlled HIV. Researchers will compare heart imaging and blood tests between 150 adults who get the extra drug and those who don't. Participant…

This phase 3 trial tests MK-8527, a once-monthly oral pill, to prevent HIV-1 infection in women. About 4580 HIV-negative women will take either MK-8527 monthly or a daily PrEP pill (Truvada) to see which works better and is safer. The goal is to offer a more convenient prevention…

This large phase 3 trial is testing whether a new oral pill called MK-8527, taken just once a month, can prevent HIV infection as well as the standard daily PrEP pill. About 4,390 people at risk of HIV will be randomly assigned to receive either the monthly pill or daily Truvada …

This study tests a new way to offer HIV prevention pills (PrEP) to people visiting family planning clinics in Kenya. Instead of requiring a separate appointment, HIV counselors will provide PrEP screening and prescriptions right at the family planning visit. The goal is to see if…

This pilot study is testing whether chiropractic care can improve quality of life and reduce inflammation in adults with HIV. Researchers will compare a group receiving weekly chiropractic adjustments to a group receiving no treatment. The study aims to see if a larger trial is p…

This study tests whether a 5-session online program teaching positive thinking skills can help people with HIV who use stimulants. Researchers want to see if it reduces stimulant use and depression by changing brain and immune function. 189 participants will be followed for 3 mon…

This study tests whether a very brief, persuasive message—delivered by a video or a counselor—can increase HIV and hepatitis C testing among emergency room patients who initially said no. About 2,000 adults who speak English or Spanish and haven't been tested in the past year wil…

This study looks at how adults in France choose to get tested for HIV voluntarily. Researchers will survey 1,000 people aged 18 and older to see which testing methods they use, such as doctor prescriptions, free testing centers, or self-tests. The goal is to learn more about test…