HGG
Clinical trials for HGG explained in plain language.
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New pill combo takes on Hard-to-Treat cancers
Disease control Recruiting nowThis early-stage trial tests two experimental pills (PF-07799544 and PF-07799933) taken twice daily at home by adults with advanced solid tumors that have a specific gene change called BRAF V600. The study aims to find safe doses and see if the drugs can shrink tumors. About 124 …
Matched conditions: HGG
Phase: PHASE1 • Sponsor: Pfizer • Aim: Disease control
Last updated Aug 16, 2026 00:00 UTC
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New hope for hard-to-treat BRAF cancers: drug targets tumor drivers
Disease control Recruiting nowThis study tests a drug called FORE8394 (plixorafenib) in people aged 10 and older whose cancers have specific BRAF gene changes. The goal is to see if the drug can shrink tumors or slow their growth. About 254 participants with advanced solid tumors or brain tumors will take the…
Matched conditions: HGG
Phase: PHASE2 • Sponsor: Fore Biotherapeutics • Aim: Disease control
Last updated Jul 29, 2026 00:00 UTC
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Experimental brain cancer drug NRG-103 enters first human tests
Disease control Recruiting nowThis early-stage trial tests an experimental drug called NRG-103 in about 24 adults with recurrent or progressive high-grade glioma, an aggressive brain cancer. The main goals are to find a safe dose and check for side effects, while also looking for early signs that the drug mig…
Matched conditions: HGG
Phase: PHASE1 • Sponsor: Neuregen Therapeutics Co., Ltd. • Aim: Disease control
Last updated Jul 19, 2026 00:00 UTC
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Sound wave helmet aims to boost brain cancer treatment
Disease control Recruiting nowThis early study tests a special helmet that uses focused ultrasound to temporarily open the blood-brain barrier in people with glioblastoma. The goal is to let more chemotherapy reach the tumor. Ten adults who have already had surgery and standard chemo will receive the ultrasou…
Matched conditions: HGG
Phase: PHASE1 • Sponsor: Sunnybrook Health Sciences Centre • Aim: Disease control
Last updated Jun 26, 2026 17:44 UTC
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Glow-in-the-Dark drug could help surgeons spot brain cancer
Knowledge-focused Recruiting nowThis early-phase trial tests a special version of the immunotherapy drug nivolumab that has a fluorescent dye attached (nivo800). The dye makes the drug glow under near-infrared light, allowing researchers to see exactly where the drug goes in the tumor during surgery. About 38 a…
Matched conditions: HGG
Phase: EARLY_PHASE1 • Sponsor: Eben Rosenthal • Aim: Knowledge-focused
Last updated Jul 03, 2026 00:00 UTC