New pill targets hard-to-treat BRAF cancers in phase 2 trial

NCT ID NCT05503797

Recruiting now Disease control Sponsor: Fore Biotherapeutics Source: ClinicalTrials.gov ↗

First seen Oct 31, 2025 · Last updated Apr 28, 2026 · Updated 27 times

Summary

This study tests a drug called FORE8394 (plixorafenib) in people with advanced solid tumors or brain tumors that have specific BRAF gene changes. The goal is to see if the drug can shrink tumors or slow their growth. About 254 participants aged 10 and older will take the pill and be monitored for response and side effects.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

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Locations

Atrium Health Wake Forest Baptist - Comprehensive Cancer Center
RECRUITING

Winston-Salem, North Carolina, 27157, United States
Baylor Scott & White Medical Center
RECRUITING

Temple, Texas, 43205, United States
Baylor Scott & White Research Institute
RECRUITING

Dallas, Texas, 75246, United States
Catholic University of Korea Saint Vincent's Hospital
RECRUITING

Suwon, Gyeonggi-do, 16247, South Korea
Centre Hospitalier Universitaire Sainte-Justine
RECRUITING

Montreal, Quebec, H3T 1C5, Canada
Charité - Universitätsmedizin Berlin
RECRUITING

Berlin, 13353, Germany
Chonnam National University Hwasun Hospital
RECRUITING

Hwasun, Jeollanam-do, 58128, South Korea
Columbia University Irving Medical Center
RECRUITING

New York, New York, 10032, United States
Dana-Farber Cancer Institute
NOT_YET_RECRUITING

Boston, Massachusetts, 02215, United States
Dong-A University Hospital
RECRUITING

Pusan, Gyeongsangnam-do, 602-812, South Korea
Flinders Medical Centre
RECRUITING

Bedford Park, South Australia, 5042, Australia
Gustave Roussy
RECRUITING

Villejuif, Val-de-Marne, 94805, France
Haukeland Univeritetssjukehus
NOT_YET_RECRUITING

Bergen, Hordaland, 5021, Norway
Hospital Clinico Universitarlo de Santiago
RECRUITING

Santiago de Compostela, A Coruña, 15706, Spain
Hospital Clinico Universitarlo de Valencia
RECRUITING

Valencia, Valencia, 46010, Spain
Hospital Infantil Universitario Niño Jesús
RECRUITING

Madrid, 28009, Spain
Hospital Universitari Vall d'Hebron
RECRUITING

Barcelona, 08035, Spain
Hospital Universitario 12 de Octubre
RECRUITING

Madrid, 28041, Spain
Hospital Universitario Virgen del Rocío
RECRUITING

Seville, 41013, Spain
Hôpital Morvan
RECRUITING

Brest, Finistère, 29200, France
Hôpital Nord de Marseille
RECRUITING

Marseille, Bouches-du-Rhône, 13005, France
Hôpital Universitaire Pitié Salpêtrière
RECRUITING

Paris, Île-de-France Region, 75013, France
Institut Bergonie
RECRUITING

Bordeaux, Aquitaine, 33000, France
Institut Universitaire du Cancer de Toulouse Oncopole
RECRUITING

Toulouse, 31059, France
Institut de Cancerologie de l'Ouest- Angers
RECRUITING

Angers, Pays de la Loire Region, 49055, France
Istituto Europeo di Oncologia
RECRUITING

Milan, 20141, Italy
Istituto Nazionale Tumori IRCCS Fondazione G. Pascale
RECRUITING

Naples, Naples, 80131, Italy
Istituto Romagnolo per lo Studio dei Tumori "Dino Amadori" - IRST
RECRUITING

Meldola, Forli-Cesena, 47014, Italy
Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) - Ospedale San Raffaele
RECRUITING

Milan, 20132, Italy
Karolinska Universitetssjukhuset
RECRUITING

Solna, Stockholm County, 171 64, Sweden
Krankenhaus Nordwest
ACTIVE_NOT_RECRUITING

Frankfurt am Main, Hesse, 60488, Germany
Lifespan Cancer Institute - Rhode Island Hospital
RECRUITING

Providence, Rhode Island, 02903, United States
Maryland Oncology Hematology- Columbia
RECRUITING

Rockville, Maryland, 20850, United States
Massachusetts General Hospital
RECRUITING

Boston, Massachusetts, 02214, United States
Memorial Sloan Kettering Cancer Center
RECRUITING

New York, New York, 10065, United States
Mosaic Life Care at Saint Joseph - Medical Center
RECRUITING

Saint Joseph, Missouri, 64506, United States
Nationwide Children's Hospital
RECRUITING

Columbus, Ohio, 43205, United States
Nebraska Cancer Specialists - Midwest Cancer Center - Legacy
RECRUITING

Omaha, Nebraska, 68130, United States
Newcastle Private Hospital
RECRUITING

New Lambton Heights, New South Wales, 2305, Australia
Norwalk Hospital
RECRUITING

Norwalk, Connecticut, 06856, United States
Orange Health Service
RECRUITING

Orange, New South Wales, 2800, Australia
Oslo Universitetssykehus-Radiumhospitalet
NOT_YET_RECRUITING

Oslo, 0379, Norway
Overlook Medical Center
RECRUITING

Summit, New Jersey, 07901, United States
Precision NextGen Oncology & Research Center
RECRUITING

Beverly Hills, California, 90210, United States
SCRI - TriStar Medical Group Children's Specialists
RECRUITING

Nashville, Tennessee, 37203, United States
SCRI Oncology Partners
RECRUITING

Nashville, Tennessee, 37203, United States
Sarah Cannon Research Institute
RECRUITING

London, W1G 6AD, United Kingdom
Seoul National University Hospital
RECRUITING

Suwon, Gyeonggido, 443-721, South Korea
Seoul National University Hospital
RECRUITING

Seoul, Seoul Teugbyeoisi, 03080, South Korea
Severance Hospital
RECRUITING

Seoul, Seoul Teugbyeolsi, 03722, South Korea
Skånes Universitetssjukhus
RECRUITING

Lund, Skåne County, 221 85, Sweden
St. Luke's Hospital
RECRUITING

Duluth, Minnesota, 55805, United States
Sunny brook Health Sciences Centre- Bayview Campus
RECRUITING

Toronto, Ontario, M4N 3M5, Canada
Sydney Children's Hospital Network - Randwick
RECRUITING

Randwick, New South Wales, 2031, Australia
Taylor Cancer Research Center
RECRUITING

Maumee, Ohio, 43537, United States
The Alfred
RECRUITING

Melbourne, Victoria, 3004, Australia
The Christie NHS Foundation Trust
RECRUITING

Manchester, England, M20 4BX, United Kingdom
The John Hopkins Hospital
RECRUITING

Baltimore, Maryland, 21287, United States
Thomas Jefferson University
RECRUITING

Philadelphia, Pennsylvania, 19107, United States
Toledo Clinic Cancer Center
COMPLETED

Toledo, Ohio, 43623, United States
Tufts Medical Center
RECRUITING

Boston, Massachusetts, 02111, United States
UCSF Helen Diller Family Comprehensive Cancer Center
RECRUITING

San Francisco, California, 94143, United States
University of California Los Angeles Rheumatology
RECRUITING

Westwood, Los Angeles, California, 90095-6984, United States
University of Miami Hospital and Clinics
RECRUITING

Miami, Florida, 33136, United States
University of Washington School of Medicine
RECRUITING

Seattle, Washington, 98109, United States
Universitätsklinikum Heidelberg
RECRUITING

Heidelberg, Baden-Wurttemberg, 69120, Germany
West Virginia University Health Sciences Campus
RECRUITING

Morgantown, West Virginia, 26506, United States

Conditions

Explore the condition pages connected to this study.

CANCER HARBORING BRAF ALTERATIONS HGG LGG SOLID TUMORS SOLID TUMORS