HER2-POSITIVE METASTATIC BREAST CANCER
Clinical trials for HER2-POSITIVE METASTATIC BREAST CANCER explained in plain language.
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New drug targets Cancer's fuel line in first human trial
Disease control Recruiting nowThis early-phase study tests a new drug called BBO-10203 in people with advanced solid tumors (breast, colorectal, or lung cancer) that have not responded to standard treatments. The drug works by blocking a key cancer growth signal (PI3Kα:RAS). The main goals are to find a safe …
Matched conditions: HER2-POSITIVE METASTATIC BREAST CANCER
Phase: PHASE1 • Sponsor: TheRas, Inc., d/b/a BBOT (BridgeBio Oncology Therapeutics) • Aim: Disease control
Last updated May 17, 2026 07:06 UTC
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PET scan could predict best next drug for advanced breast cancer
Disease control Recruiting nowThis study is for people with advanced HER2-positive breast cancer whose disease has worsened after a drug called T-DXd. Researchers will use a special PET scan to see if the cancer still has HER2 on its surface. If the scan is positive, participants get a different drug called T…
Matched conditions: HER2-POSITIVE METASTATIC BREAST CANCER
Phase: PHASE2 • Sponsor: Jules Bordet Institute • Aim: Disease control
Last updated May 15, 2026 11:56 UTC
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New drug cocktail targets breast cancer that invaded the brain
Disease control Recruiting nowThis study tests whether a combination of two oral drugs (tucatinib and capecitabine) plus a chemotherapy given directly into the spinal fluid (trastuzumab) can help people with HER2-positive breast cancer that has spread to the lining of the brain and spinal cord. About 30 adult…
Matched conditions: HER2-POSITIVE METASTATIC BREAST CANCER
Phase: PHASE2 • Sponsor: UNICANCER • Aim: Disease control
Last updated May 15, 2026 11:53 UTC
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Brain scan surveillance trial aims to catch metastases early in HER2+ breast cancer
Knowledge-focused Recruiting nowThis study looks at whether it's possible to routinely scan the brain in people with HER2-positive metastatic breast cancer to find hidden brain tumors early. About 69 participants will get a baseline brain MRI, and if no tumors are found, they are randomly assigned to either fol…
Matched conditions: HER2-POSITIVE METASTATIC BREAST CANCER
Phase: NA • Sponsor: Royal College of Surgeons, Ireland • Aim: Knowledge-focused
Last updated May 17, 2026 06:52 UTC
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New test aims to match breast cancer patients with the right drug
Knowledge-focused Recruiting nowThis study is testing a new, more precise way to measure HER2 protein levels in people with metastatic breast cancer. The goal is to see if this test can better predict who will benefit from a targeted drug called T-DXd. Researchers will enroll 200 adults with HER2-low breast can…
Matched conditions: HER2-POSITIVE METASTATIC BREAST CANCER
Sponsor: Abramson Cancer Center at Penn Medicine • Aim: Knowledge-focused
Last updated May 15, 2026 11:57 UTC