Can a better HER2 test predict who responds to targeted therapy?
NCT ID NCT06551116
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study is testing a new, more precise method to measure HER2 levels in leftover tumor tissue from people with HER2-low metastatic breast cancer. The goal is to see if this test can accurately tell who will respond to the drug T-Dxd. Researchers will enroll 200 participants and compare the test results with actual treatment outcomes.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
quantitative HER2 assay (diagnostic test on leftover tumor tissue)
What this could lead to
If successful, this could lead to a more accurate test that helps doctors identify which patients with HER2-low breast cancer will benefit from targeted therapy like T-Dxd.
What could go wrong
This is an early diagnostic study, not a treatment trial. The test may not reliably predict response, and results may not change patient outcomes.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Abramson Cancer Center of the University of Pennsylvania
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
RECRUITINGHouston, Texas, 77054, United States
Contact Email: •••••@•••••
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Ben Taub General Hospital
RECRUITINGHouston, Texas, 77030, United States
Contact Email: •••••@•••••
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Georgetown University - Lombardi CCC
RECRUITINGWashington D.C., District of Columbia, 20007, United States
Contact Email: •••••@•••••
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John's Hopkins Hospital
RECRUITINGBaltimore, Maryland, 21287, United States
Contact Email: •••••@•••••
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MD Anderson Cancer Center
RECRUITINGHouston, Texas, 77079, United States
Contact Email: •••••@•••••
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MD Anderson Cancer Center
RECRUITINGSugar Land, Texas, 77478, United States
Contact Email: •••••@•••••
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MD Anderson Cancer center
RECRUITINGHouston, Texas, 77030, United States
Contact Email: •••••@•••••
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MD Anderson Cancer center
RECRUITINGLeague City, Texas, 77573, United States
Contact Email: •••••@•••••
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MD Anderson Cancer center
RECRUITINGWoodland, Texas, 77384, United States
Contact Email: •••••@•••••
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MedStar Washington Hospital Center
RECRUITINGWashington D.C., District of Columbia, 20010, United States
Contact Email: •••••@•••••
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Montefiore Einstein Medical Center
RECRUITINGThe Bronx, New York, 10467, United States
Contact Email: •••••@•••••
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Penn Medicine Princeton Medical Center
RECRUITINGPlainsboro, New Jersey, 08536, United States
Contact Email: •••••@•••••
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Sibley Memorial Hospital
RECRUITINGWashington D.C., District of Columbia, 20016, United States
Contact Email: •••••@•••••
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Smilow Cancer Hospital Care Center
RECRUITINGFairfield, Connecticut, 06824, United States
Contact Email: •••••@•••••
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Smilow Cancer Hospital Care Center
RECRUITINGGuilford, Connecticut, 06437, United States
Contact Email: •••••@•••••
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Smilow Cancer Hospital Care Center
RECRUITINGTrumbull, Connecticut, 06611, United States
Contact Email: •••••@•••••
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Smilow Cancer Hospital Care Center
RECRUITINGWesterly, Rhode Island, 02891, United States
Contact Email: •••••@•••••
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Smilow Cancer Hospital Care Center - Waterford
RECRUITINGWaterford, Connecticut, 06385, United States
Contact Email: •••••@•••••
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Smilow Cancer Hospital Care Center at Greenwich
RECRUITINGGreenwich, Connecticut, 06830, United States
Contact Email: •••••@•••••
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Smilow Cancer Hospital Care Center at Long Ridge
RECRUITINGStamford, Connecticut, 06901, United States
Contact Email: •••••@•••••
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Smilow Cancer Hospital at Glastonbury
RECRUITINGGlastonbury, Connecticut, 06033, United States
Contact Email: •••••@•••••
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Smilow Cancer Hospital at Saint Francis
RECRUITINGHartford, Connecticut, 06105, United States
Contact Email: •••••@•••••
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Smilow Cancer Hospital-Derby Care Center
RECRUITINGDerby, Connecticut, 06418, United States
Contact Email: •••••@•••••
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Smilow Cancer Hospital-Torrington Care Center
RECRUITINGTorrington, Connecticut, 06790, United States
Contact Email: •••••@•••••
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Smilow Cancer Hospital-Waterbury Care Center
RECRUITINGWaterbury, Connecticut, 06708, United States
Contact Email: •••••@•••••
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UNC Chapel Hill
RECRUITINGChapel Hill, North Carolina, 27599, United States
Contact Email: •••••@•••••
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UPMC Hillman CC
RECRUITINGPittsburgh, Pennsylvania, 15232, United States
Contact Email: •••••@•••••
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University of California San Francisco Medical Center
RECRUITINGSan Francisco, California, 94143, United States
Contact Email: •••••@•••••
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University of Chicago Comprehensive Cancer Center at Silver Cross
RECRUITINGNew Lenox, Illinois, 60451, United States
Contact Email: •••••@•••••
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University of Chicago Medical Center
RECRUITINGChicago, Illinois, 60637, United States
Contact Email: •••••@•••••
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University of Chicago Medicine Northwest Indiana
RECRUITINGCrown Point, Indiana, 46307, United States
Contact Email: •••••@•••••
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University of Chicago Medicine-Orland Park
RECRUITINGOrland Park, Illinois, 60462, United States
Contact Email: •••••@•••••
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University of Pittsburgh Medical Center
RECRUITINGPittsburgh, Pennsylvania, 15213, United States
Contact Email: •••••@•••••
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University of Washington - Fred Hutchinson Cancer Center
RECRUITINGSeattle, Washington, 98109, United States
Contact Email: •••••@•••••
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Yale Cancer Center
RECRUITINGNew Haven, Connecticut, 06511, United States
Contact
Contact Email: •••••@•••••
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Yale-New Haven Hospital North Haven Medical Center
RECRUITINGNew Haven, Connecticut, 06473, United States
Contact Email: •••••@•••••