Can a better HER2 test predict who responds to targeted therapy?

NCT ID NCT06551116

Recruiting now Diagnosis Sponsor: Abramson Cancer Center at Penn Medicine Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 09, 2026 · Updated 3 times

Summary

This study is testing a new, more precise method to measure HER2 levels in leftover tumor tissue from people with HER2-low metastatic breast cancer. The goal is to see if this test can accurately tell who will respond to the drug T-Dxd. Researchers will enroll 200 participants and compare the test results with actual treatment outcomes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: quantitative HER2 assay (diagnostic test on leftover tumor tissue)
What this could lead to: If successful, this could lead to a more accurate test that helps doctors identify which patients with HER2-low breast cancer will benefit from targeted therapy like T-Dxd.
What could go wrong: This is an early diagnostic study, not a treatment trial. The test may not reliably predict response, and results may not change patient outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

HER2 positive breast carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HER2-POSITIVE METASTATIC BREAST CANCER

Contacts and locations

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Locations

Abramson Cancer Center of the University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19104, United States

Contact Email: •••••@•••••
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
RECRUITING

Houston, Texas, 77054, United States
Ben Taub General Hospital
RECRUITING

Houston, Texas, 77030, United States
Georgetown University - Lombardi CCC
RECRUITING

Washington D.C., District of Columbia, 20007, United States
John's Hopkins Hospital
RECRUITING

Baltimore, Maryland, 21287, United States
MD Anderson Cancer Center
RECRUITING

Houston, Texas, 77079, United States
MD Anderson Cancer Center
RECRUITING

Sugar Land, Texas, 77478, United States
MD Anderson Cancer center
RECRUITING

Houston, Texas, 77030, United States
MD Anderson Cancer center
RECRUITING

League City, Texas, 77573, United States
MD Anderson Cancer center
RECRUITING

Woodland, Texas, 77384, United States
MedStar Washington Hospital Center
RECRUITING

Washington D.C., District of Columbia, 20010, United States
Montefiore Einstein Medical Center
RECRUITING

The Bronx, New York, 10467, United States
Penn Medicine Princeton Medical Center
RECRUITING

Plainsboro, New Jersey, 08536, United States
Sibley Memorial Hospital
RECRUITING

Washington D.C., District of Columbia, 20016, United States
Smilow Cancer Hospital Care Center
RECRUITING

Fairfield, Connecticut, 06824, United States
Smilow Cancer Hospital Care Center
RECRUITING

Guilford, Connecticut, 06437, United States
Smilow Cancer Hospital Care Center
RECRUITING

Trumbull, Connecticut, 06611, United States
Smilow Cancer Hospital Care Center
RECRUITING

Westerly, Rhode Island, 02891, United States
Smilow Cancer Hospital Care Center - Waterford
RECRUITING

Waterford, Connecticut, 06385, United States
Smilow Cancer Hospital Care Center at Greenwich
RECRUITING

Greenwich, Connecticut, 06830, United States
Smilow Cancer Hospital Care Center at Long Ridge
RECRUITING

Stamford, Connecticut, 06901, United States
Smilow Cancer Hospital at Glastonbury
RECRUITING

Glastonbury, Connecticut, 06033, United States
Smilow Cancer Hospital at Saint Francis
RECRUITING

Hartford, Connecticut, 06105, United States
Smilow Cancer Hospital-Derby Care Center
RECRUITING

Derby, Connecticut, 06418, United States
Smilow Cancer Hospital-Torrington Care Center
RECRUITING

Torrington, Connecticut, 06790, United States
Smilow Cancer Hospital-Waterbury Care Center
RECRUITING

Waterbury, Connecticut, 06708, United States
UNC Chapel Hill
RECRUITING

Chapel Hill, North Carolina, 27599, United States
UPMC Hillman CC
RECRUITING

Pittsburgh, Pennsylvania, 15232, United States
University of California San Francisco Medical Center
RECRUITING

San Francisco, California, 94143, United States
University of Chicago Comprehensive Cancer Center at Silver Cross
RECRUITING

New Lenox, Illinois, 60451, United States
University of Chicago Medical Center
RECRUITING

Chicago, Illinois, 60637, United States
University of Chicago Medicine Northwest Indiana
RECRUITING

Crown Point, Indiana, 46307, United States
University of Chicago Medicine-Orland Park
RECRUITING

Orland Park, Illinois, 60462, United States
University of Pittsburgh Medical Center
RECRUITING

Pittsburgh, Pennsylvania, 15213, United States
University of Washington - Fred Hutchinson Cancer Center
RECRUITING

Seattle, Washington, 98109, United States
Yale Cancer Center
RECRUITING

New Haven, Connecticut, 06511, United States
Yale-New Haven Hospital North Haven Medical Center
RECRUITING

New Haven, Connecticut, 06473, United States

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