HEMATOLOGIC NEOPLASMS

This study is testing three different flu vaccines in 60 adults with blood cancers like leukemia or lymphoma. The goal is to find out which vaccine triggers the strongest immune response in people with weakened immune systems. Participants will receive one of the vaccines and hav…

This study tests an experimental drug called KK2430 in people with blood cancers (hematologic neoplasms). It is the first time this drug is given to humans, so the main goals are to check safety, how the body handles the drug, and whether it can shrink tumors. About 72 adults wit…

This early-phase study tests a new drug called JNJ-95804306 in people with blood cancers (like leukemia) that have returned or not responded to standard treatments. The main goals are to check safety and find the best dose. About 280 participants will take part, and the study wil…

This study compares two strategies to prevent bleeding in adults receiving a stem cell transplant for blood cancer. One group gets standard preventive platelet transfusions, while the other gets a drug called tranexamic acid plus platelet transfusions only if needed. The goal is …

This study tests whether giving donor white blood cells (lymphocytes) soon after a stem cell transplant can lower the chance of cancer returning in people with high-risk blood cancers like leukemia or lymphoma. Participants receive chemotherapy, a stem cell transplant, and then a…

This study tests a new approach for people with aggressive blood cancers that have not responded well to standard treatments. It combines two powerful therapies: a half-matched bone marrow transplant and specially engineered CAR T-cells that target a protein called CD19 on cancer…

This study is for adults aged 18-85 with blood cancers that haven't responded well to standard treatments. It tests whether a lower dose of the drug cyclophosphamide, given after a bone marrow transplant, can reduce side effects while still preventing graft-versus-host disease (a…

This study tests whether red blood cells stored with less oxygen (hypoxic RBCs) are safer and more effective than standard transfusions for people with blood cancers who need regular blood. About 24 adults with transfusion-dependent blood cancers will receive both types of blood …

This study tests whether a computer brain-training program (Lumosity) can improve memory and thinking in adults who had a stem cell transplant for blood cancer. About 60 survivors, 3 to 6 months after transplant, will either start training right away or wait 12 weeks. The goal is…

This study tests whether a mind-body group program can help reduce fatigue in people who have finished treatment for blood cancers like leukemia or lymphoma. About 94 participants will be randomly assigned to the program or usual care. The goal is to see if this supportive approa…

This study from Mayo Clinic is looking at 2000 people who have early warning signs like unexplained low blood counts or certain genetic changes in their blood cells. Researchers are using a special genetic test to see if they can spot who is at risk for developing blood cancers o…

This study looks at how cancer impacts not just patients, but their entire family. Researchers will survey 240 Danish adults with breast, prostate, colorectal cancer, or lymphoma, along with their caregivers. The goal is to understand family health, needs, and support to identify…

This study enrolls up to 10,000 adults with cancer to see how often doctors follow recommendations from a special team (molecular tumor board) that reviews each patient's tumor genetic test results. Researchers will track whether these personalized treatment suggestions actually …

This study tests whether using artificial intelligence (AI) to rewrite hospital discharge letters in plain language helps cancer patients better understand their medical information. About 150 adults with blood cancer or other cancers will take part. Some will get the standard le…

This study collects blood, bone marrow, urine, and tissue samples from people with solid tumors, blood cancers, or non-cancerous blood disorders, as well as from healthy family members who are stem cell donors. The samples are used in lab research to better understand diseases, i…