HEALTHY CONTROLS

This study tests a new PET imaging method that uses 10 to 100 times less radiation than standard scans to detect neuroendocrine tumors. About 200 healthy volunteers and people with tumors will receive a radioactive tracer and be scanned with a high-sensitivity PET machine. The go…

This early study is testing whether a gentle, personalized brain stimulation technique called tACS can safely help with depression during pregnancy. Researchers will enroll 10 women (some with depression, some healthy) to check if the approach is safe, tolerable, and feasible. Th…

This study tests whether a technique called Graded Motor Imagery (GMI) — a series of mental exercises that involve thinking about and visualizing ankle movements — can improve pain, stiffness, strength, and balance in people with chronic ankle instability. About 48 adults (half w…

This study looks at whether a single session of whole-body heat therapy, with or without a cold water plunge, can reduce symptoms of depression. Researchers will enroll 162 adults aged 18-65 who currently have depressive symptoms. Participants will be randomly assigned to receive…

This observational study tests whether DANU Smart Socks can accurately measure walking and balance in people with Parkinson's disease. Researchers will compare data from 60 participants (30 with Parkinson's and 30 healthy older adults) during a single lab visit. The goal is to se…

This study uses PET and MRI scans to look at serotonin pathways in the brainstem of adults with Dravet syndrome, a severe form of epilepsy. The goal is to see if these pathways are different in Dravet patients compared to those with other drug-resistant epilepsy and healthy volun…

This study creates a repository of microbiome samples (like stool, saliva, and skin swabs) from up to 600 people of all ages, including healthy volunteers and those with various conditions. Researchers will use these samples to study how the microbiome affects health and disease,…

This study uses brain scans (fMRI) to understand why people with bipolar disorder experience unstable moods compared to healthy individuals. Researchers will ask 72 participants to recall personal memories and practice boosting positive feelings while their brain activity is reco…

This early-phase study tests a new radioactive tracer called [11C]SY08 to see if it can detect clumps of alpha-synuclein protein in the brain using PET scans. Researchers will scan 40 volunteers, including healthy people and those with Parkinson's disease, multiple system atrophy…

This study explores whether very small, barely noticeable movements can help retrain the brain's balance system in people with inner ear problems. Researchers will test balance and motion sensitivity in 48 adults with certain balance disorders and healthy volunteers. The goal is …

This study uses brain scans to measure the density of connections between brain cells in people with cocaine use disorder compared to healthy volunteers. Researchers aim to understand how cocaine affects brain plasticity. The study involves 80 participants aged 21-60, including t…

This study looks at how two rare diseases that cause blood vessel inflammation—Takayasu arteritis and Behçet's disease—affect physical strength, breathing, daily function, and emotional well-being. Researchers will compare 30 participants (patients and healthy volunteers) using s…

This study tests whether low-intensity focused ultrasound (LIFU) can safely and temporarily change how different parts of the brain communicate with each other. Researchers will apply LIFU to deep brain areas in 66 healthy adults and measure brain activity changes using MRI scans…

This study looks at how the antipsychotic medication haloperidol may block insulin action in the brain, which could explain why these drugs often cause weight gain and diabetes. Researchers will give healthy volunteers either haloperidol or a placebo and use brain scans to measur…

This study tests a new, non-invasive brain stimulation technique called transcranial interference stimulation (tIS) in 10 healthy adults. The goal is to see if it is safe and how it affects brain activity and the ability to recognize emotions in faces. If successful, this researc…

This study looks at why people with Lewy body dementia have sudden changes in their ability to think clearly, known as cognitive fluctuations. Researchers will use brain scans and EEG to measure brain changes in 120 participants, including those with dementia and healthy voluntee…

This study looks at how a substance called HA35 affects muscle protein balance in healthy people. Over 4 days, 24 participants will take either HA35 or a placebo capsule, then undergo tests including blood work, muscle biopsies, and a gut permeability test. The goal is to underst…