HEAD NECK CANCER

This study tests a new drug called OM-RCA-01 in people with several types of cancer that have spread to other parts of the body and have a specific marker (FGFR1). The drug is an antibody given through a vein every two weeks. The main goals are to find a safe dose and see if it c…

This early-stage trial tests a new drug, VLPONC-01, injected directly into tumors in people with head and neck cancer. The study aims to see if it is safe and whether combining it with an immunotherapy drug (pembrolizumab) can shrink tumors better than the immunotherapy alone. Ab…

This early-stage trial tests a new drug (RiMO-301) combined with targeted radiation and an immunotherapy drug (a PD-1 inhibitor) in people with advanced head and neck cancer that cannot be removed by surgery or has spread. The goal is to find a safe dose and see if the treatment …

This phase 3 trial tests a new treatment for people with high-risk head and neck cancer who cannot receive the standard chemotherapy drug cisplatin. Participants receive radiation therapy combined with two drugs (nimotuzumab and benmelstobart) to see if this approach improves dis…

This early-stage study tests a new treatment for adults with head and neck cancer that has come back or spread. The treatment combines a virus-based injection (EDS01) directly into a tumor with an immunotherapy drug (toripalimab) given through a vein. The goal is to see if the co…

This study tests whether giving a combination of two drugs (nimotuzumab and toripalimab) plus chemotherapy before surgery can help people with advanced tonsil cancer. The goal is to see if the tumors shrink or disappear completely, making surgery more effective. Ten adults with r…

This study tests whether adding the targeted drug nimotuzumab to standard radiation therapy helps control advanced head and neck cancer better than radiation alone. It is for 335 adults whose cancer has spread locally but who cannot take platinum-based chemotherapy. The main goal…

This study tests a combination of three treatments—nimotuzumab, an immunotherapy (PD-1 inhibitor), and chemotherapy—for people with advanced head and neck cancer that can still be surgically removed. The goal is to see if this mix improves how long patients live without the cance…

This early study tests a new imaging agent called FL-261 in 12 adults with advanced cancers (lung, colorectal, head & neck). The agent targets a protein on cancer cells and is tracked by PET or SPECT scans to see if it can find tumors and their spread more accurately than current…

This study tests whether a special PET-CT scan (micro-PET-CT) can accurately show where head and neck cancer ends, compared to standard lab tests. Ten adults with operable head and neck tumors will have their surgical specimens scanned and then checked under a microscope. If succ…

This study tests if a special ultrasound using a contrast agent (Sonazoid) can find the first lymph node where cancer might spread, called the sentinel node. It involves 91 adults with melanoma, breast cancer, or head & neck cancer who are already scheduled for surgery. If succes…

This early-stage study tests a non-invasive procedure that uses focused ultrasound to create a tiny lesion in the brain's pain center. It is for 20 adults with head, neck, or brachial cancer whose pain is not controlled by opioids. The goal is to see if it is safe and can reduce …

This study is testing whether a special nurse-led care plan can help people recover better after head and neck cancer surgery. The plan includes extra support from nurses, dietitians, and counselors to reduce complications and improve quality of life. About 80 adults having surge…

This study looks at what head and neck cancer patients and dentists know about dental care during cancer treatment. About 132 people will fill out a questionnaire before and after reading simple, guideline-based information. The goal is to see if the educational materials help im…

This study is looking at whether a special PET scan taken 6 weeks after starting immunotherapy can predict how well the treatment will work at 3, 6, and 9 months. It involves 25 adults with advanced head and neck cancer that has come back or spread. The goal is to see if early ch…

This study looks at using proton therapy for head and neck cancer that returns after previous radiation treatment. Proton therapy aims to target the tumor more precisely and spare healthy tissues. Researchers will track side effects, tumor control, survival, and quality of life i…

This study looks at genetic and immune changes in laryngeal dysplasia, a precancerous condition of the voice box, to find markers that predict progression to cancer. Researchers will analyze tissue samples from 3 participants to compare immune cell counts in low- and high-risk le…