HEAD AND NECK SQUAMOUS CELL CARCINOMA

This study tested whether giving the immunotherapy drug durvalumab alongside radiation works better than the standard cetuximab plus radiation for people with advanced head and neck cancer who cannot take the usual chemotherapy drug cisplatin. A total of 196 adults took part. The…

This study tested whether adding lenvatinib to the standard immunotherapy drug pembrolizumab helps people with advanced head and neck cancer that has come back or spread. 112 adults with a specific marker (PD-L1 positive) took part. The goal was to see if the combination shrinks …

This study tested a new drug combination (IO102-IO103 plus pembrolizumab) as a first treatment for people with advanced lung, head/neck, or bladder cancer that had spread. The goal was to see if the combo could shrink tumors and delay cancer growth. 63 people took part, and the s…

This study tested whether adding tadalafil (a drug for erectile dysfunction) to pembrolizumab (an immunotherapy) could help people with advanced head and neck cancer that had come back or spread. Seven adults with measurable disease took part. The main goals were to check safety …

This study tested a new drug called RPH-002 against the standard drug Erbitux in 118 people with advanced head and neck cancer that could not be removed by surgery. The main goals were to compare how the drugs move through the body and to check their safety when used with chemoth…

This study tested a special smoking cessation program called ETIP in 19 patients with head and neck or lung cancer. The program included counseling, medication, and nicotine replacement to help patients cut down or quit smoking. Researchers also checked if reducing smoking change…

This trial tested a new treatment for a type of head and neck cancer linked to the Epstein-Barr virus (EBV). The treatment uses specially engineered immune cells (TCR-T cells) that can recognize and attack the cancer, plus they release a substance to block a common cancer defense…

This study tested a new treatment for a type of head and neck cancer linked to HPV-16. The treatment combined an HPV vaccine (ISA101b), an immunotherapy drug (pembrolizumab), and standard chemo-radiation. The goal was to see if this mix could help control the cancer for longer. T…

This study tested a new way to give radiation for head and neck cancer. Instead of treating the whole neck, doctors used artificial intelligence to focus radiation only on the cancer spots. 67 patients took part to see if this approach could reduce side effects without increasing…

This study tested a treatment plan for people with advanced head and neck cancer that cannot be removed by surgery. The plan combined the immunotherapy drug camrelizumab with chemotherapy and radiation. 39 adults took part. The goal was to see if the treatment could help control …

This early-stage trial tested a new treatment for people with HPV16-positive head and neck or cervical cancer that has spread or come back. The therapy uses a patient's own immune cells, modified to recognize and attack HPV-infected cancer cells, with some cells also engineered t…

This study collected tumor samples from 419 people with head and neck cancer to create a biobank. Researchers will use these samples in future genomic studies to find factors that predict how well a person will respond to treatment. The goal is to improve personalized outcome pre…

This study looked at whether a type of MRI called diffusion-weighted MRI (DW-MRI) can predict if head and neck cancer will come back after chemoradiotherapy. Researchers scanned 59 patients shortly after treatment and tracked them for up to a year. The goal was to see if changes …

This study tested a new blood test (liquid biopsy) to find cancer markers in 135 people with head and neck, lung, or skin cancer. The goal was to see if the blood test works as well as a standard tissue biopsy. The study did not provide treatment but aimed to improve how doctors …

This study looked at 40 patients with advanced head and neck cancer to see if a personalized blood test could find tiny bits of tumor DNA (ctDNA) before and after surgery and during follow-up. The goal was to learn if this test could help predict if the cancer would come back. Th…