GIANT CELL ARTERITIS (GCA)

This study looks at whether people with giant cell arteritis (GCA) who are in remission can safely stop or lower their dose of tocilizumab (Actemra) without the disease coming back. Participants must have been on high-dose tocilizumab for at least a year and off steroids for thre…

This study looks at whether two medications, dapagliflozin and bosentan, can improve blood vessel function in people with large vessel vasculitis (LVV), a condition that raises the risk of heart attacks and strokes. About 60 adults with stable LVV will take both drugs for 6 weeks…

This study looks at whether measuring a protein called thrombomodulin in the blood can help doctors rule out giant cell arteritis (GCA) in people with polymyalgia rheumatica (PMR). About 78 adults over 50 with PMR will give a blood sample before starting steroids. If the test wor…

This study looks at whether measuring the optic nerve sheath with ultrasound can reliably diagnose giant cell arteritis (GCA), a condition that causes inflammation in blood vessels. Researchers will enroll 190 people over age 50 with suspected GCA and compare ultrasound measureme…

This study is testing a new blood test that may help doctors choose the most effective drug for each person with rheumatic diseases like rheumatoid arthritis or lupus. The test looks at how a person's immune cells react to different medications before treatment starts. The goal i…

This study tests whether a low dose of hydrocortisone can relieve symptoms like fatigue and feeling unwell in people who have stopped taking prednisolone for giant cell arteritis (GCA) or polymyalgia rheumatica (PMR). About 100 adults aged 50 and older who have been off steroids …

This study is looking for 340 people with suspected giant cell arteritis (GCA), a condition that causes inflammation in blood vessels and is usually treated with long-term steroids. The goal is to find better ways to predict who will have relapses and to monitor the disease using…