GIANT CELL ARTERITIS

This study tests whether the drug abatacept can help people with giant cell arteritis, a condition that causes inflammation in blood vessels. About 78 adults with newly diagnosed or relapsing disease will receive either abatacept or a placebo for up to 12 months. The goal is to s…

This study looks at whether a lower-resolution MRI can reliably detect giant cell arteritis, a condition that inflames arteries and can cause blindness or stroke if not treated quickly. Researchers will compare different MRI scans in 133 adults suspected of having the disease. If…

This study tests whether a new imaging agent called AzaFol, used with a PET/CT scan, can improve diagnosis of giant cell arteritis (GCA), a condition where blood vessels become inflamed. About 70 adults aged 50 and older with suspected GCA will receive one AzaFol-PET/CT scan. The…

This study tests whether taking extra hydrocortisone during times of stress (like illness or emotional strain) can improve quality of life, especially fatigue, in people with polymyalgia rheumatica (PMR) or giant cell arteritis (GCA) who are already on low-dose prednisolone. Abou…

This study collects DNA samples and medical information from 1,000 people with various forms of vasculitis (blood vessel inflammation). Researchers will analyze the data to identify genes that increase the risk of developing these severe diseases. The goal is to better understand…

This study looks at whether ultrasound images of the temporal and axillary arteries can help predict when giant cell arteritis (GCA) will flare up again. Researchers will follow 100 people with GCA to see if certain ultrasound patterns are linked to relapses. The goal is to impro…

This study tests whether MRI scans can detect inflammation in the arteries of the head, brain, and eyes in people with suspected giant cell arteritis (GCA). Researchers will enroll 400 adults aged 50 and older with new or worsening symptoms and high inflammation levels. The goal …

This study follows 400 adults with giant cell arteritis or polymyalgia rheumatica to see how often serious aortic problems (like aneurysms) and steroid-related side effects occur over time. Researchers will track these events using medical records and a special steroid toxicity s…

This study gathers existing tissue samples from 1,000 people with various forms of vasculitis, a group of rare diseases that cause blood vessel inflammation. Researchers will analyze the tissue alongside medical data to find genes linked to the disease. The goal is to better unde…

This study is building a large registry and biorepository of 5000 adults with various rheumatic diseases like rheumatoid arthritis and lupus. Researchers will collect medical information and biological samples over time to identify patterns and biomarkers. The goal is to better u…

This study follows up to 4,000 people with vasculitis (a group of diseases that cause blood vessel inflammation) and healthy volunteers over many years. Researchers collect blood, urine, imaging, and genetic samples to learn how the disease develops and changes. The goal is to fi…