GASTROESOPHAGEAL CANCER

This study tests a new drug, MK-2870, against standard treatments for people with advanced stomach, esophageal, or gastroesophageal junction cancer that has not responded to earlier therapies. About 450 participants will be randomly assigned to receive either MK-2870 or a treatme…

This early-phase trial is testing whether giving immunotherapy drugs (nivolumab alone or with relatlimab) before standard chemoradiation is safe and feasible for people with operable stage II/III esophageal or gastroesophageal junction cancer. The study involves 32 participants a…

This study tests whether adding targeted radiation to the immunotherapy drug nivolumab (alone or with another drug, relatlimab) can help control advanced stomach, esophageal, or gastroesophageal junction cancer. About 21 adults with limited metastatic disease will receive radiati…

This study tests a new treatment approach for people with advanced stomach or gastroesophageal junction cancer that has spread. Participants first receive targeted radiation and a drug called olaparib, followed by a combination of olaparib and pembrolizumab. The goal is to see if…

This study aimed to see if immunotherapy drugs (nivolumab with or without ipilimumab) could help people with colorectal or gastroesophageal cancer avoid or delay major surgery. It planned to enroll adults with early-stage cancers. However, the study was withdrawn before any parti…

This early-phase trial tests a combination of two drugs, naptumomab estafenatox and durvalumab, in adults with advanced solid tumors that have not responded to standard treatments. The main goal is to find a safe dose and check for side effects. About 120 people with various canc…

This study tests a program that provides nutrition support remotely to people with gastroesophageal cancer who are getting chemotherapy and radiation. The program uses a mobile app for logging food and includes meetings with a dietitian. The goal is to see if the program is pract…

This study tests a program that lets cancer patients receive care at home through remote monitoring during chemotherapy or radiation. The goal is to see if this approach reduces hospital visits and emergency department stays. About 300 adults with certain cancers (like pancreatic…

This study aimed to collect blood and tumor tissue from people with gastroesophageal cancer to look for genetic changes linked to immunotherapy resistance. It was an observational study, meaning no treatment or drugs were tested. The study was withdrawn before enrolling any parti…

This study looks for early signs of heart injury in people receiving radiation therapy for lung or esophageal cancer. Researchers use heart scans and blood tests to detect changes during or shortly after treatment. The goal is to identify patients at risk for heart problems and i…