ESOPHAGEAL NEOPLASMS

This study tests whether adding omega-3 fatty acids (EPA and DHA) to standard immunotherapy (PD-1 inhibitors) helps adults with advanced esophageal cancer. The main goal is to see if omega-3 can prevent muscle loss and improve treatment outcomes. About 142 participants will recei…

This trial tests a new drug, UCB4594, designed to help the immune system attack cancer cells by targeting a protein called HLA-G found on many tumors. It is for people with advanced solid cancers that have not responded to standard treatments. The study aims to find the safest do…

This study tests a new drug called LY4337713, which delivers radiation directly to cancer cells that have a specific protein (FAP). It is for adults with advanced or spread-out cancers like pancreatic, breast, ovarian, colorectal, esophageal, stomach, or bile duct cancer. The mai…

This study compares two surgical procedures—removing part or all of the stomach—for people with advanced cancer where the esophagus meets the stomach. About 120 participants will be randomly assigned to one surgery or the other. The goal is to see which approach leads to longer c…

This study tests two new drug combinations for people with advanced stomach, gastroesophageal junction, or esophageal cancer that has gotten worse after one prior treatment. About 210 participants will receive either an experimental antibody-drug combo plus standard chemo, or sta…

This study tests whether adding new investigational drugs to standard chemotherapy and immunotherapy (pembrolizumab) can safely treat advanced stomach, gastroesophageal junction, or esophageal cancer that has not spread to other organs. About 160 adults whose cancer is HER2-negat…

This study tests a 6-week program combining bright light exposure with specific exercises to improve sleep, mood, and quality of life in people with lung or esophageal cancer. Researchers will track 200 participants' sleep patterns, symptoms, and survival rates for one year. The …

This study is testing a new questionnaire to better understand and track symptoms in people with upper digestive diseases or who have had esophageal surgery. Researchers will ask 1000 patients to complete the survey at different times. The goal is to create a standard tool that h…

This study looks back at medical records of 2,000 adults who had endoscopic removal of cancerous or precancerous growths in the esophagus, stomach, duodenum, colon, or rectum. The goal is to compare different removal methods to see which is safest and most effective at completely…