END-STAGE KIDNEY DISEASE

This study compared two types of home dialysis for people with end-stage kidney disease: nighttime automated dialysis (APD) and daytime manual dialysis (CAPD). 137 non-diabetic adults tried each method for 12 weeks. The goal was to see if nighttime dialysis was as good as daytime…

This study tested whether a new training package called TEACH-PD could lower infection rates in patients starting peritoneal dialysis (PD). Over 1,400 adults from multiple countries were randomly assigned to receive either the TEACH-PD training or standard PD training. The resear…

This study tested an experimental drug called MK-2060 in 506 adults with end-stage kidney disease who need regular dialysis through a special tube (graft) in their arm. The goal was to see if the drug could prevent dangerous blood clots from blocking the graft, which would requir…

This study tested a special collagen implant coated with sirolimus (rapamycin) placed around a new dialysis fistula during surgery. The goal was to see if it helps the fistula become usable for dialysis sooner and stay working longer. About 269 people with advanced kidney disease…

This phase 3 trial tests a sirolimus-releasing collagen implant placed around a new dialysis fistula during surgery. The goal is to help the fistula mature faster so it can be used for dialysis. The study involves 136 people aged 65+ with kidney failure who are new to hemodialysi…

This early study tested a single shot of an experimental drug called MK-2060 in 14 people with stage 4 chronic kidney disease. The main goal was to see if it was safe and how the body handles it. Only the first part of the study was completed; the later parts were not started for…

This study tested a drug called PLS240 in 412 adults with end-stage kidney disease on dialysis who also have overactive parathyroid glands (secondary hyperparathyroidism). Participants received either PLS240 or a placebo intravenously three times a week for 27 weeks, followed by …

This study tested a drug called nemolizumab to see if it can reduce severe itching in adults with chronic kidney disease who are on dialysis. 258 participants received either nemolizumab or a placebo as injections every 4 weeks for 12 weeks. The main goal was to see how many peop…

This study tested whether a home-based digital brain training program could help with depression, thinking skills, and quality of life in 36 people with cancer or end-stage kidney disease. Participants used a computer program called Rejuvenate for 30 minutes, four times a week, f…

This study tests whether advanced ultrasound techniques (2D and 3D speckle-tracking echocardiography) can detect early signs of heart muscle dysfunction in children aged 4 to 18 with end-stage kidney disease who have been on dialysis for at least a year. Researchers aim to see if…

This study looked at whether a 12-week cycling program during hemodialysis can reduce heart muscle stress (called stunning) in adults with end-stage kidney disease. 111 participants either cycled or rested during their dialysis sessions. Researchers measured heart function with u…

This study looked at whether adjusting the amount of magnesium in the dialysis fluid could help keep blood magnesium levels in a healthy range for people with kidney failure on hemodialysis. Fifty-four adults took part in this pilot crossover trial. The goal was to gather informa…

This pilot study tested a shared decision-making tool called the Donor Offer Plan (DOP) for people on the kidney transplant waiting list. 100 participants reviewed an online education module and discussed their donor preferences with a transplant nurse. The goal was to see if thi…

This study tested a single dose of the drug AZD4144 in 41 adults with severe kidney disease, end-stage kidney disease, and healthy volunteers. Researchers measured how the drug moves through the body and checked for side effects. The goal was to understand how kidney problems aff…

This study tested a patient-friendly website and printouts to help kidney transplant candidates compare transplant centers. Researchers wanted to see if the new format helped people understand which centers accept patients like them. A total of 268 adults waiting for a kidney tra…

This completed Phase 1 study looked at how the drug MK-5684 behaves in the body of men with severe kidney disease or end-stage renal disease compared to healthy men. Twenty-four participants received a single dose, and researchers measured drug levels in the blood over time. The …