CRITICALLY ILL

This study looks at how medicines behave in the bodies of up to 2,000 critically ill children under 21 in the heart intensive care unit. Researchers collect leftover blood samples and medical data to better understand drug dosing and safety. No new drugs are given—only standard c…

This study checks if measuring oxygen in exhaled air through a facemask is reliable for critically ill patients who need a breathing tube. Low oxygen is a common complication during this procedure. Researchers will compare facemask readings to a more direct measurement in the thr…

This study looks back at medical records of critically ill adults in the ICU who needed a breathing tube. Researchers want to see if the type of medicine used to sedate them before intubation affects their chance of dying within a week. The goal is to find out which drug is safes…

This study tests whether measuring the thickness of a chest muscle (parasternal intercostal) can help doctors decide the best time to remove a breathing tube. 200 critically ill adults on ventilators will be randomly assigned to standard weaning or weaning guided by this muscle m…

This study looks at 30 ICU patients starting a type of kidney therapy (continuous renal replacement therapy) to remove extra fluid. Researchers want to see if a measure called the Analgesia Nociception Index (ANI), which tracks the balance between the 'fight or flight' and 'rest …