CRITICALLY ILL
Clinical trials for CRITICALLY ILL explained in plain language.
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New breathing tube method may prevent lung infections in ICU
Disease control CompletedThis study tested whether continuously monitoring and adjusting the pressure in the breathing tube's cuff (the balloon that seals the airway) could reduce stomach fluid from leaking into the lungs. The study involved 122 critically ill patients on ventilators who were receiving t…
Matched conditions: CRITICALLY ILL
Phase: PHASE4 • Sponsor: University Hospital, Lille • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
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Fast pneumonia test could save ICU patients from wrong antibiotics
Diagnosis CompletedThis study tested a rapid diagnostic test (BioFire Pneumonia Panel) in 40 ICU patients on ventilators with suspected pneumonia. Half got the rapid test, half got standard care. The goal was to see if the test helps doctors give the right antibiotics sooner. Results could lead to …
Matched conditions: CRITICALLY ILL
Phase: PHASE2 • Sponsor: Chinese University of Hong Kong • Aim: Diagnosis
Last updated Jun 27, 2026 09:10 UTC
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Vitamin d trial aims to shield kidneys in critical illness
Prevention CompletedThis study tested whether giving activated vitamin D (calcifediol and calcitriol) to critically ill patients in the ICU could prevent or lessen acute kidney injury (AKI). Researchers enrolled 150 adults at high risk for AKI. The goal was to see if this treatment could reduce deat…
Matched conditions: CRITICALLY ILL
Phase: PHASE2 • Sponsor: David Leaf • Aim: Prevention
Last updated Jun 27, 2026 07:52 UTC
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Tube tool tested: does a stylet boost First-Attempt intubation success?
Knowledge-focused CompletedThis study looked at whether using a bendable wire (stylet) inside the breathing tube helps doctors successfully insert the tube on the first attempt in critically ill patients. Over 1,000 adults in intensive care who needed a breathing tube took part. The goal was to see if the …
Matched conditions: CRITICALLY ILL
Phase: NA • Sponsor: University Hospital, Montpellier • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC
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ICU suction procedure questioned: new study looks at lung effects
Knowledge-focused CompletedThis study looked at whether suctioning the windpipe (tracheal suction) during removal of a breathing tube affects lung volume in critically ill patients. Researchers measured lung volume changes in 60 ICU patients before and after extubation, comparing those who received suction…
Matched conditions: CRITICALLY ILL
Sponsor: University Hospital, Rouen • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:04 UTC
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Breath test may predict ventilator success in ICU patients
Knowledge-focused CompletedThis study looked at 120 critically ill patients on breathing machines to see if a quick, non-invasive test called P0.1 could predict whether they would need the tube reinserted after removal. The test measures the effort to breathe in the first split second of inhalation. Resear…
Matched conditions: CRITICALLY ILL
Sponsor: Cleveland Clinic Abu Dhabi • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:36 UTC
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Can extra protein help sick kids leave the ICU sooner?
Knowledge-focused CompletedThis study tested whether adding extra protein to standard feeding helps underweight critically ill children recover faster. Researchers enrolled 34 children aged 28 days to 18 years who were on breathing support in the intensive care unit (PICU). The goal was to see if this appr…
Matched conditions: CRITICALLY ILL
Phase: NA • Sponsor: KK Women's and Children's Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:30 UTC
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Anemia duration may predict ventilator days in ICU patients
Knowledge-focused CompletedThis study examined 236 adults in a surgical intensive care unit who needed a breathing machine for more than 4 days. Researchers wanted to see if the length of time a patient had anemia (low red blood cells) was linked to how long they stayed on the ventilator. The goal was to b…
Matched conditions: CRITICALLY ILL
Sponsor: Mahidol University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:29 UTC
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Global experts aim to settle debate on ICU airway care
Knowledge-focused CompletedThis study brings together 35 healthcare professionals from around the world to agree on the best methods for clearing mucus from the airways of intubated, critically ill patients. Using a Delphi process, experts will vote on statements about humidification, inhaled therapies, su…
Matched conditions: CRITICALLY ILL
Sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:06 UTC
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New kidney test could improve drug dosing in ICU patients
Knowledge-focused CompletedThis study tested a more accurate method to measure kidney function in 90 critically ill ICU patients whose kidneys were working overtime. The standard creatinine clearance test can be misleading in these patients, so researchers compared it with the iohexol plasma clearance tech…
Matched conditions: CRITICALLY ILL
Phase: NA • Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:03 UTC
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What happens to the sickest COVID patients? french ICU study aims to find out
Knowledge-focused CompletedThis study followed over 1,000 adults with confirmed or suspected COVID-19 who were admitted to intensive care units (ICUs) across France. Researchers tracked their treatments, complications, and survival at 28 days. The goal was to learn how these patients are managed and what f…
Matched conditions: CRITICALLY ILL
Sponsor: Centre Hospitalier Universitaire de Nīmes • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:00 UTC