CRITICAL LIMB ISCHEMIA
Clinical trials for CRITICAL LIMB ISCHEMIA explained in plain language.
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New stent could save legs from amputation in artery disease patients
Disease control CompletedThis study tested a temporary metal stent designed to open blocked arteries below the knee in people with peripheral artery disease or critical limb ischemia. The goal was to improve blood flow and prevent serious complications like amputation or death. A total of 130 participant…
Matched conditions: CRITICAL LIMB ISCHEMIA
Phase: NA • Sponsor: ReFlow Medical, Inc. • Aim: Disease control
Last updated May 17, 2026 11:39 UTC
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Gene therapy injection shows promise for leg pain from blocked arteries
Disease control CompletedThis study tested a gene therapy called VM202 (Engensis) in 52 people with critical limb ischemia, a severe blockage of leg arteries causing pain and risk of amputation. Participants received injections into the calf muscle to see if it safely improves blood flow and reduces pain…
Matched conditions: CRITICAL LIMB ISCHEMIA
Phase: PHASE2 • Sponsor: Helixmith Co., Ltd. • Aim: Disease control
Last updated May 14, 2026 12:04 UTC
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New Vein-Artery connection saves limbs when all else fails
Disease control CompletedThis study tested a device that creates a new connection between a vein and an artery below the knee to restore blood flow in people with critical limb ischemia, a severe blockage that can lead to amputation. The 28 participants had no other treatment options. The goal was to see…
Matched conditions: CRITICAL LIMB ISCHEMIA
Phase: NA • Sponsor: LimFlow SA • Aim: Disease control
Last updated May 13, 2026 16:03 UTC
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One artery or many? new study tests best way to save legs from amputation
Disease control CompletedThis study looked at 40 people with severe leg artery blockages (critical limb ischemia) to see if opening one blocked artery with angioplasty works as well as opening several. The main goal was to save the leg from major amputation and help wounds heal. Researchers compared outc…
Matched conditions: CRITICAL LIMB ISCHEMIA
Phase: NA • Sponsor: Aswan University • Aim: Disease control
Last updated May 13, 2026 15:59 UTC
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Leg-Saving procedure offers hope for patients with no other options
Disease control CompletedThis study tested a device that creates a small connection between a vein and artery below the knee to reroute blood flow in people with critical limb ischemia, a severe condition where blocked arteries cause pain and wounds. The goal was to see if this procedure could help avoid…
Matched conditions: CRITICAL LIMB ISCHEMIA
Phase: NA • Sponsor: LimFlow SA • Aim: Disease control
Last updated May 11, 2026 20:51 UTC
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New gene therapy injection tested for leg artery disease
Disease control CompletedThis early-phase study tested whether a gene therapy called VM202 is safe for people with critical limb ischemia, a severe form of peripheral artery disease that causes pain and wounds. Twelve adults who had not improved with standard treatments received injections into their leg…
Matched conditions: CRITICAL LIMB ISCHEMIA
Phase: PHASE1 • Sponsor: Helixmith Co., Ltd. • Aim: Disease control
Last updated May 06, 2026 16:00 UTC
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Simple tests could save thousands of diabetic legs from amputation
Diagnosis CompletedThis study looked at 604 people with diabetes to see how well simple bedside tests (like listening to blood flow with a Doppler) can detect poor leg circulation compared to detailed scans (CTA or MRA). Poor circulation is a major cause of leg amputations in diabetes, but finding …
Matched conditions: CRITICAL LIMB ISCHEMIA
Sponsor: Imperial College London • Aim: Diagnosis
Last updated May 14, 2026 12:04 UTC