CRITICAL LIMB ISCHEMIA
Clinical trials for CRITICAL LIMB ISCHEMIA explained in plain language.
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New procedure reroutes blood to save limbs when all else fails
Disease control CompletedThis study tested a device called the LimFlow System for patients with severe leg circulation problems (critical limb ischemia) who had no other surgical or minimally invasive options left. The device creates a new connection between an artery and a vein below the knee to bypass …
Matched conditions: CRITICAL LIMB ISCHEMIA
Phase: NA • Sponsor: LimFlow SA • Aim: Disease control
Last updated Apr 02, 2026 03:42 UTC
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New device offers hope to prevent amputation in patients with no other options
Disease control CompletedThis study tested a device called the LimFlow System in patients with severe leg circulation problems who were facing amputation and had no other surgical options. The device uses a small incision to reroute blood from an artery into a vein to restore blood flow to the foot. The …
Matched conditions: CRITICAL LIMB ISCHEMIA
Phase: NA • Sponsor: LimFlow SA • Aim: Disease control
Last updated Apr 02, 2026 03:42 UTC
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Study finds opening more leg arteries saves limbs better
Disease control CompletedThis study compared two approaches for treating severe leg artery blockages (critical limb ischemia). Researchers tested whether opening one blocked artery versus multiple blocked arteries with angioplasty led to better outcomes. They found that opening multiple arteries resulted…
Matched conditions: CRITICAL LIMB ISCHEMIA
Phase: NA • Sponsor: Aswan University • Aim: Disease control
Last updated Apr 01, 2026 14:54 UTC
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Experimental gene injection aims to save limbs from amputation
Disease control CompletedThis study tested whether injections of an experimental drug called VM202 (Engensis) into the calf muscle could help people with severe blockages in their leg arteries, a condition called critical limb ischemia. The goal was to see if the drug could safely promote new blood vesse…
Matched conditions: CRITICAL LIMB ISCHEMIA
Phase: PHASE2 • Sponsor: Helixmith Co., Ltd. • Aim: Disease control
Last updated Apr 01, 2026 14:40 UTC
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Temporary stent tested to save limbs from amputation
Disease control CompletedThis study tested a new, temporary stent device designed to open severely blocked arteries below the knee in patients with advanced peripheral artery disease. The goal was to improve blood flow to relieve pain, heal wounds, and prevent amputations. Researchers followed 130 patien…
Matched conditions: CRITICAL LIMB ISCHEMIA
Phase: NA • Sponsor: ReFlow Medical, Inc. • Aim: Disease control
Last updated Mar 27, 2026 12:40 UTC
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Gene therapy tested as last hope for patients facing amputation
Disease control CompletedThis early-stage study tested the safety of a new gene therapy called VM202 (Engensis) in 12 people with critical limb ischemia, a severe form of poor leg circulation causing pain and ulcers. The goal was to see if injections into the leg muscle were safe and if they might improv…
Matched conditions: CRITICAL LIMB ISCHEMIA
Phase: PHASE1 • Sponsor: Helixmith Co., Ltd. • Aim: Disease control
Last updated Mar 24, 2026 12:02 UTC
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Simple tests could save diabetic feet from amputation
Diagnosis CompletedThis study aimed to find the best simple bedside test for detecting poor leg circulation (peripheral arterial disease) in people with diabetes. Researchers compared several quick tests, like blood pressure measurements in the ankle and toe, against more complex imaging scans. The…
Matched conditions: CRITICAL LIMB ISCHEMIA
Sponsor: Imperial College London • Aim: Diagnosis
Last updated Mar 12, 2026 13:52 UTC