COLORECTAL (COLON OR RECTAL) CANCER

This phase I trial tests a surgical procedure called utero-ovarian transposition (UOT) to temporarily move the uterus, ovaries, and fallopian tubes out of the radiation field in women aged 18-40 with pelvic cancers. The goal is to preserve fertility and ovarian function during wh…

This early-phase trial tests a new drug called CBI-1214 in 80 people with advanced colorectal cancer that has not responded to standard treatments. CBI-1214 is designed to connect the body's own immune T cells to cancer cells, helping the immune system attack the tumor. The main …

This study tests a new drug called RC148 combined with chemotherapy as a first treatment for people with advanced colorectal cancer that cannot be surgically removed. About 80 participants will receive either RC148 plus chemo or the standard bevacizumab plus chemo. The goal is to…

This study tests whether using hypnosis during a screening colonoscopy helps people feel less anxious and in less pain, and whether it helps doctors complete the exam more fully. About 600 adults in France will be randomly assigned to receive either standard care or hypnosis duri…

This study looks at whether giving lidocaine or ketamine during colorectal cancer surgery can lower inflammation (measured by a substance called IL-6) and help patients feel better after the operation. About 50 adults having open colorectal surgery will receive one of the two dru…

This study investigates clonal hematopoiesis (CH) — small mutations in blood cells that can arise naturally or after cancer treatment — in adults receiving chemotherapy or radiation for solid tumors like breast, lung, or colorectal cancer. Researchers will collect blood, saliva, …

This early study tests whether a non-invasive sound wave procedure called histotripsy can stir up the immune system in people with colorectal cancer that has spread to the liver. Researchers will take blood samples before and after treatment to see if T-cells become more active. …