Sound wave therapy may spark immune attack on liver tumors

NCT ID NCT07361107

Recruiting now Knowledge-focused Sponsor: Northwell Health Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This early study tests whether a non-invasive sound wave procedure called histotripsy can stir up the immune system in people with colorectal cancer that has spread to the liver. Researchers will take blood samples before and after treatment to see if T-cells become more active. Only 12 people will take part, and the goal is to understand the immune response, not yet to treat the cancer.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Histotripsy (a non-invasive procedure using sound waves to destroy tumors)
What this could lead to: If it works, this could point toward combining histotripsy with immunotherapy to better treat colorectal cancer that has spread to the liver.
What could go wrong: This is a very early, small pilot study with only 12 people. It is designed to measure immune changes, not to prove the treatment works. The results may not lead to any new treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

colonic neoplasm colorectal cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COLORECTAL (COLON OR RECTAL) CANCER

Contacts and locations

Locations

Zuckerberg Cancer Center
RECRUITING

New Hyde Park, New York, 11040, United States

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