CARDIOMYOPATHIES

This early-stage study tests a gene therapy called AAVrh.10hFXN for heart disease caused by Friedreich's ataxia, a rare genetic disorder. The therapy delivers a working copy of the frataxin gene via a single IV infusion. The main goal is to check safety in 25 people aged 12 to 50…

This study tests a special pacing technique called high-intensity his bundle pacing in 34 adults with heart failure and a narrow QRS pattern on their ECG. Standard pacing doesn't help these patients, but this new approach may improve heart function and quality of life. Participan…

This study tests whether colchicine, a common anti-inflammatory drug, can help people with chronic heart muscle inflammation (inflammatory cardiomyopathy). About 80 adults with this condition will receive either colchicine or a placebo to see if it prevents worsening heart failur…

This study tests the Cardiohelp device, a heart-lung machine for children with severe heart failure, to see if it is safe and works well for up to 30 days. It also compares two blood thinners, heparin and bivalirudin, to find which causes fewer bleeding or clotting problems. Abou…

This study tests if a non-invasive radiation treatment (SBRT) can reduce dangerous heart rhythms as well as the standard catheter ablation procedure in 60 people with advanced heart disease. Participants will be randomly assigned to receive either radiation or catheter ablation. …

This study tests whether destroying small areas of heart tissue that cause abnormal rhythms (ablation) during LVAD implant surgery can reduce dangerous heart rhythms after surgery. About 100 adults with advanced heart failure who are getting an LVAD will be included. The goal is …

This study tests an experimental drug called acoramidis in 587 adults who carry a gene that puts them at high risk for transthyretin amyloidosis (ATTR), a condition where sticky plaques damage the heart and nerves. The goal is to see if taking acoramidis early can prevent or dela…

This study is testing a new AI-powered software called Willem that reads electrocardiograms (ECGs) to detect heart rhythm problems. Researchers will compare the AI's readings to those of expert cardiologists using data from over 5,000 high-risk heart patients. The goal is to see …

This study tests whether a wrist-worn sensor (PPG) can estimate how well the heart pumps blood, compared to standard ultrasound. About 500 adults getting an echocardiogram will wear the device. If successful, this could lead to simpler, cheaper heart monitoring.

This study follows 36 people aged 12 and older who have a genetic heart condition called PKP2-ACM. Researchers will monitor heart rhythms, biomarkers, and quality of life to learn how the disease progresses under standard care. No new treatments are tested—the goal is to gather i…

This study involves 60 people with advanced heart failure who have a HeartMate 3 heart pump. The goal is to develop a way to monitor heart function using only data from the pump itself, without extra tests. Researchers will compare this new method with standard procedures like ul…

This study looks for new genes and blood markers linked to arrhythmogenic cardiomyopathy, a genetic heart condition that can cause sudden cardiac arrest. Researchers will enroll 1,000 people with the condition or their family members from the US and UK. By collecting medical data…

This study looks at heart tissue samples from 216 adults who already need a biopsy as part of their care. Researchers want to find unique molecular patterns in different heart conditions, including after a heart transplant. The goal is to improve how these diseases are diagnosed …

This study creates an online registry for 10,000 adults with cardiomyopathy or myocarditis (heart muscle diseases). Researchers will track health events like heart failure, arrhythmias, and death over time to better understand these conditions. Participants join from home and are…

This study follows 1500 people with heart failure who have an implantable defibrillator (ICD) to prevent sudden cardiac death. Researchers want to learn why some people are at higher risk than others by looking at heart structure, electrical signals, genetics, and blood proteins.…

This study is looking for genetic heart problems that might cause sudden unexpected death in people with epilepsy. Researchers will test the DNA of 600 adults with epilepsy or related conditions, plus their relatives, to find known heart-related gene mutations. The goal is to bet…