BREAST DUCTAL CARCINOMA IN SITU

This study tests a vaccine called H2NVAC in people with a very early form of breast cancer called DCIS that has the HER2 protein. The vaccine is given before surgery to see if it can train the immune system to fight the cancer and possibly prevent it from coming back. The main go…

This study looks at whether eating fewer calories while getting focused radiation (SABR) before surgery can shrink breast tumors more than radiation alone. About 80 adults with early-stage breast cancer will be randomly assigned to one of two groups. The goal is to see if the com…

This study tests a new glowing needle that helps doctors find and sample very small abnormal areas inside breast ducts during surgery. The needle has a special coating that lights up, making it easier to see and remove the right tissue. About 300 women having breast duct surgery …

This study looks at whether adding high-dose omega-3 fatty acids to low-dose tamoxifen can better reduce breast cancer risk in overweight postmenopausal women who are already at higher risk. Tamoxifen blocks estrogen, which can fuel some breast cancers, while omega-3s may help wi…

This study tests whether a low dose of tamoxifen can safely reduce breast density—a key risk factor for breast cancer—in premenopausal women at higher-than-average risk. About 200 women will receive a response-guided dose, with adjustments based on how their breast density change…

This study tests two drugs, acolbifene and low-dose tamoxifen, to see which works better at preventing breast cancer in premenopausal women at high risk. Both drugs block estrogen from fueling breast cell growth. About 80 women will take one of the drugs for six months, and resea…

This study tests a high-CBD plant extract (BRC-001) to see if it can reduce joint pain and stiffness in women with breast cancer who take aromatase inhibitors (AIs). AIs lower estrogen to prevent cancer return but often cause arthritis-like side effects, leading some women to sto…

This study looks at how the COVID-19 pandemic impacted the financial costs for breast cancer patients having surgery, including out-of-pocket expenses and lost wages. Researchers will survey 600 patients to understand the economic strain and how the pandemic may have made things …

This study offers free genetic testing to the general public to find people with inherited cancer syndromes, like hereditary breast and ovarian cancer or Lynch syndrome. Researchers want to see if broad testing is better than only testing those with a family history. Up to 27,500…

This study tests a patient navigation program for women newly diagnosed with breast cancer. The program helps patients understand their care options, connect with support services, and overcome barriers like transportation or financial concerns. Researchers will measure how many …