AUTONOMIC FAILURE

This study tests a simple device that lets people rebreathe some of their own exhaled CO2 to raise blood pressure. It is for adults with neurogenic orthostatic hypotension, a condition where blood pressure drops sharply upon standing, causing dizziness or fainting. Researchers wi…

This study looks at whether using a CPAP machine (commonly used for sleep apnea) can lower high blood pressure when lying down at night and help with dizziness upon standing in people with autonomic failure. About 59 adults aged 40-80 with conditions like Parkinson's disease or m…

This study looks at whether a CPAP machine, often used for sleep apnea, can safely lower high blood pressure that happens when people with autonomic failure lie down. About 12 adults with this condition will try CPAP while researchers measure changes in their blood pressure and n…

This study looks at whether raising the head of the bed can help lower high blood pressure that occurs when lying down (supine hypertension) in people with autonomic failure. By using gravity to reduce blood flow returning to the heart, researchers hope to find a non-drug way to …

This study tests whether applying gentle heat to the belly overnight can safely lower high blood pressure in people with autonomic failure who also have high blood pressure when lying down. About 20 adults with conditions like Parkinson's or Multiple System Atrophy will be monito…

This study uses a special PET scan to measure dopamine production in the brains of people with autonomic failure, including those with Parkinson's disease, Multiple System Atrophy, or Dementia with Lewy Bodies. The goal is to find early signs that predict if a person with pure au…

This study looks at how two medications, midodrine and droxidopa, affect the veins in the abdomen of people with autonomic failure—a condition where the body can't control blood pressure properly. Researchers will measure changes in heart function when participants are tilted upr…