APLASTIC ANEMIA

This study tests a new stem cell transplant method for adults aged 40 to 60 with severe aplastic anemia that did not improve or came back after standard drug therapy. The approach uses a drug called cyclophosphamide after transplant to reduce the risk of graft-versus-host disease…

This study tests whether Darzalex Faspro can safely lower donor-specific antibodies (DSAs) in adults with blood cancers who are at high risk of rejecting a stem cell transplant. Participants receive the drug before standard transplant preparation to reduce DSA levels enough to al…

This study tests whether a special exercise program combined with a vitamin-like supplement (called NR) can help teens and young adults who had a bone marrow transplant rebuild lost muscle and improve their fitness. About 80 participants, ages 10 to 30, will be randomly assigned …

This study tests whether adding the drug ruxolitinib to standard care can prevent graft-versus-host disease (GVHD) in older adults with aplastic anemia who receive a stem cell transplant. GVHD is a common and serious complication where donor cells attack the patient's body. The t…

This study tests a mix of drugs that calm the immune system and boost white blood cells in people with aplastic anemia or certain types of MDS. The goal is to improve low blood counts by targeting immune cells that may be attacking the bone marrow. About 140 adults will take part…

This study tests a two-step, lower-intensity approach using radiation and chemotherapy before a stem cell transplant for people with various blood cancers or disorders. The goal is to see if this gentler preparation reduces the risk of death from the transplant itself. About 63 p…

This study looks at how well umbilical cord blood stem cells from unrelated donors can restore blood cell counts in people with serious blood cancers, immune deficiencies, or genetic disorders. Researchers will track how often the transplant succeeds, how long it takes for blood …

This study looks at the safety and effectiveness of the drug Revolade (eltrombopag) in children aged 6 to 17 with aplastic anemia, a rare condition where the bone marrow stops making enough blood cells. The children in this study have not received a standard treatment called anti…

This study tests whether giving emapalumab early, right after diagnosis, can improve blood cell recovery in children with severe aplastic anemia. About 35 children will receive the drug to see if it helps standard treatments work better. The goal is to improve blood counts within…

This study is a registry that collects information from 1,000 patients with blood diseases who receive stem cell transplants at a hospital on the Qinghai-Tibet Plateau. Researchers will track their health, treatments, and costs over time to learn how high altitude affects recover…

This study is a large registry that will follow up to 2,300 people in China with various blood diseases, such as leukemia, multiple myeloma, and hemophilia. Researchers will collect information from medical records to understand how common these diseases are, what treatments peop…

This study tests a new communication tool called 'Let's Get REAL' that helps children and teens (ages 8-17) and their families talk about stem cell transplant and cellular therapy decisions. About 60 youth and their parents will try the tool, and researchers will measure if it is…

This study aims to create a prediction tool for pregnant women with aplastic anemia, a rare blood disorder that raises risks of bleeding, infection, and complications like preterm birth. Researchers will follow 300 women to identify factors that lead to poor outcomes for mother a…