ALZHEIMER DISEASE (AD)

This early-stage study tests a new vaccine called DUVAX in 24 healthy adults aged 40-65. The vaccine aims to train the immune system to attack two proteins linked to Alzheimer's disease. The main goal is to check safety and see if the vaccine produces a helpful immune response.

This study tests whether a daily supplement called tributyrin can slow memory decline in people with mild Alzheimer's disease. Over 12 weeks, 156 participants will take either tributyrin or a placebo, and researchers will measure changes in thinking skills, inflammation, and gut …

This study tests whether low-dose whole-brain radiotherapy can slow down early-onset Alzheimer's disease. Fifty adults over 50 with early-stage Alzheimer's will be randomly assigned to receive either the radiation or a sham treatment. Researchers will track changes in memory, thi…

This study tests whether a natural soy compound called genistein can slow down memory and thinking problems in people with mild cognitive impairment, often an early sign of Alzheimer's disease. Over 18 months, 150 adults aged 50+ will take either genistein or a placebo pill. Rese…

This study tests whether monoclonal antibody drugs can slow Alzheimer's disease progression in 120 people with mild cognitive impairment or mild Alzheimer's. Researchers will use PET scans to measure brain proteins and see which patients benefit most. The goal is to better target…

This study looks at whether a lower dose of the medication lecanemab can control Alzheimer's disease as well as the standard dose. Researchers will compare brain scans, thinking tests, and blood markers in 140 people with early-stage Alzheimer's over 18 months. The goal is to fin…

This study aims to speed up Alzheimer's diagnosis by using blood tests, spinal taps, and brain scans. Researchers will compare a nurse-led screening tool to standard specialist appointments. About 200 people with mild memory problems will take part to see if the new approach redu…

This early-stage study tests a nasal spray made from neural stem cell particles (exosomes) in 9 people with moderate-to-severe early-onset Alzheimer's. The main goal is to check safety and how well people tolerate different doses given over 28 days. Researchers will also look for…

This study looks at how caring for a family member with Alzheimer's disease affects caregivers' emotional health, daily life, and sense of burden, both during care and after the person dies. Researchers will interview and survey 66 current and former caregivers to understand thes…

This study tests a new AI method that could create one type of brain scan (FDG PET) from another (amyloid PET) using existing data from 35 Alzheimer's patients. If successful, future patients might only need one scan instead of two, reducing radiation, cost, and time. No new scan…

This study tests a program designed to help primary care doctors identify dementia in patients who have memory concerns but haven't been diagnosed yet. Researchers will compare this program to usual care in 80 adults over 6 months. The goal is to see if the program leads to more …