ALZHEIMER DISEASE (AD)

This early-stage study tests a new vaccine called DUVAX in 24 healthy adults aged 40-65. The vaccine aims to train the immune system to attack two proteins linked to Alzheimer's disease. The main goal is to check safety and see if the vaccine produces a protective immune response…

This early-stage study tests whether a nasal spray containing particles from neural stem cells is safe for people with moderate-to-severe early-onset Alzheimer's. Nine participants aged 50-75 will receive different dosing schedules over 28 days. The main goal is to check for side…

This study tests whether low-dose radiation to the whole brain can slow down Alzheimer's disease in people with early-onset symptoms. Fifty participants will be randomly assigned to receive either the radiation treatment or a sham procedure. Researchers will track changes in memo…

This study will test whether a lower dose of the drug lecanemab works as well as the standard dose for people with early Alzheimer's disease. Researchers will compare brain scans, memory tests, and blood markers in 140 participants over 18 months. The goal is to find the most eff…

This study tests whether a natural compound from soy, called genistein, can slow down memory and thinking problems in people with mild cognitive impairment (MCI), often an early sign of Alzheimer's disease. About 150 adults over 50 with MCI will take either genistein or a placebo…

This Phase 3 trial tests whether a daily supplement called tributyrin can slow cognitive decline in people with mild Alzheimer's disease. Over 12 weeks, 156 participants will take either tributyrin or a placebo. Researchers will measure changes in memory, thinking, gut bacteria, …

This study will test the antibody drug lecanemab in 120 people with mild cognitive impairment or mild-to-moderate Alzheimer's disease. Using PET scans to measure amyloid and tau proteins in the brain, researchers hope to identify which patients are most likely to benefit from tre…

This study tests a faster way to diagnose Alzheimer's disease using blood tests, spinal taps, and brain scans. It involves 200 people aged 50-90 with mild memory problems. The goal is to see if a nurse-led screening tool can help get a diagnosis in months instead of over a year.

This study tests whether a year-long virtual lifestyle coaching program—focusing on diet, sleep, and activity—can lower Alzheimer's-related blood markers in 1,200 adults aged 60-80 who carry a genetic risk. Participants wear an Oura ring for tracking and provide blood samples. Th…

This study aims to reduce unwanted loneliness and improve the daily experience of family caregivers for people with Alzheimer's disease. Researchers will test a combination of music therapy and health education with 50 caregivers. The goal is to see if these activities can help c…

This study uses a special full-body PET scan to look for activated T cells (a type of immune cell) in the brain and body of people with Alzheimer's disease. Ten participants with Alzheimer's and some healthy volunteers will get the scan to compare results. The goal is to better u…

This study tests a program called Improving Dementia Care (IDC) to help primary care doctors identify dementia in patients who have memory concerns but no prior diagnosis. About 80 adults with mild cognitive issues will take part. The goal is to see if the program leads to more d…

This study tests a new AI method to generate a type of brain scan (FDG PET) from another scan (amyloid PET) and an MRI, without needing an extra injection or scan. Researchers will use data from 35 Alzheimer's patients who already had both scans. If it works, it could reduce radi…

This study looks at how caring for a family member with Alzheimer's disease affects caregivers' daily lives, emotions, and sense of balance. Researchers will interview and survey 66 caregivers, some who are still caring for a loved one and some who have experienced the loss of th…