ALCOHOLISM

This study tests whether a monthly injection of naltrexone, a medication that blocks alcohol's rewarding effects, helps people who drink for pleasure reduce heavy drinking. Sixty adults with alcohol use disorder will receive either the drug or a placebo shot, plus counseling. The…

This study is testing whether a combination of ketamine (a medication) and real-time brain training (neurofeedback) can help people with alcohol use disorder reduce their drinking. About 75 adults aged 18-65 who want to cut back or stop drinking will receive either ketamine or a …

This study looks at how well a combined recovery program and home telehealth support help veterans with alcohol or drug problems. About 195 veterans in a VA inpatient unit will take part. The goal is to see if these extra services reduce substance use and improve recovery compare…

This study tests whether offering specialized alcohol treatment right in the liver clinic helps people newly diagnosed with alcohol-related liver disease stop drinking. About 221 adults will be randomly assigned to either get the alcohol treatment offer or standard care. The main…

This study tests whether tirzepatide, a drug used for diabetes and obesity, can reduce heavy drinking in people who have both schizophrenia and alcohol use disorder. About 108 participants will receive either tirzepatide or a placebo for 16 weeks. Researchers will track changes i…

This study tests a non-invasive brain stimulation device called Deep TMS to see if it can help people with moderate to severe alcohol use disorder reduce heavy drinking. About 186 adults will receive either real or fake (sham) treatment over several months. The goal is to see if …

This study tests whether adding cannabidiol (CBD) to the standard medication naltrexone helps reduce alcohol cravings more than naltrexone alone. About 150 adults with alcohol addiction who experience strong cravings will take either a high or low dose of CBD plus naltrexone, or …

This study aims to understand why medical students develop depression and other mental health issues like anxiety, suicidal thoughts, and substance abuse. Researchers will follow up to 10,000 students over 22 years, comparing those who enter medical school with those who do not. …

This study aims to create simple computer tasks that measure thinking, motivation, and decision-making in people with and without alcohol use disorders. Researchers will use MRI scans to see how the brain works during these tasks. The goal is to develop better tools for future st…

This study looks at why people with bipolar disorder may think about or attempt suicide, focusing on life experiences and biology. Researchers will test a 6-week group program to help reduce these behaviors and improve quality of life. About 130 English-speaking adults with bipol…

This study aims to understand how the brains of people with alcohol dependence differ from those without it. Researchers will use MRI scans and computer games to look at brain structure and activity. About 1,000 adults aged 18 and older will participate in a single visit. The goa…

This study aims to build a large data repository by gathering information from 10,000 adults who have used alcohol or drugs in the past 30 days. Participants will use a smartphone app that collects data like app usage and movement, and complete daily and monthly surveys about moo…

This study looks at why a single low dose of ketamine works better for some people with hard-to-treat depression. Researchers will use brain scans to measure brain activity and chemical changes in 60 adults. The goal is to find out if a family history of alcohol problems affects …