Xanthogranulomatous pyelonephritis
MONDO:0007022Chronic, destructive infection of the kidney characterized by lipid-laden macrophages in the setting of obstruction secondary to infected renal stones, most commonly caused by Proteus or Escherichia coli.
Also known as: xanthogranulomatous pyelonephritis
24 clinical trials for this condition and its sub-types.
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Can a diabetes drug protect the heart and kidneys in severe CKD?
Disease control ENROLLING_BY_INVITATIONThis Phase 3 trial tests whether dapagliflozin (Forxiga), a drug originally for diabetes, can reduce the risk of death, kidney failure, and heart failure hospitalization in 1750 people with severe chronic kidney disease. Unlike earlier studies, this trial includes patients on dia…
Phase: PHASE3 • Sponsor: University Medical Center Groningen • Aim: Disease control
Last updated Jun 27, 2026 12:36 UTC
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Why kidney patients feel so tired: muscle fatigue under the microscope
Knowledge-focused TerminatedThis study investigates why people with advanced chronic kidney disease (not yet on dialysis) often feel deep fatigue. Researchers will measure muscle strength and fatigue using simple tests like hand grip and walking speed. The goal is to understand how kidney disease affects ne…
Sponsor: Centre Hospitalier le Mans • Aim: Knowledge-focused
Last updated Jul 03, 2026 00:00 UTC
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Kidney function may affect hepatitis b drug levels
Knowledge-focused OngoingThis study gives a single dose of bepirovirsen to 32 adults with hepatitis B, some with kidney disease and some healthy. Researchers measure how much drug gets into the blood and how long it stays. The goal is to see if kidney problems change drug levels, which could affect futur…
Phase: PHASE1 • Sponsor: GlaxoSmithKline • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:37 UTC