Vulvar lichen sclerosus
MONDO:0006491A chronic inflammatory disorder of unknown etiology that affects the vulva. It is characterized by the development of white elevated plaques in the vulva. Histologically there is marked subepithelial fibrosis. Clinical manifestations include pruritus, dysuria, and dyspareunia.
Also known as: lichen sclerosus et atrophicus of mammalian vulva, mammalian vulva lichen sclerosus et atrophicus, vulvar lichen sclerosus
15 clinical trials for this condition and its sub-types.
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Laser treatment could offer new hope for chronic skin condition
Disease control CompletedThis study tested a new dual laser treatment for vulvar lichen sclerosus, a chronic skin condition causing discomfort. 66 participants were randomly assigned to receive either laser therapy or standard steroid cream. The goal was to see if the laser works as well as the cream, po…
Phase: NA • Sponsor: Prof. Dr. Volker Viereck • Aim: Disease control
Last updated Jun 27, 2026 12:00 UTC
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Could your own blood ease a painful skin condition?
Symptom relief CompletedThis study tests whether a treatment made from a patient's own blood (platelet-rich plasma) is safe and can reduce symptoms of vulvar lichen sclerosus, a chronic skin condition causing itching and pain. About 30 adult women will receive either the plasma treatment or a placebo. R…
Phase: PHASE1, PHASE2 • Sponsor: Jennifer R. Arthurs • Aim: Symptom relief
Last updated Jul 24, 2026 00:00 UTC
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Tattoo machine vs. needle: new hope for women with genital skin disease?
Symptom relief CompletedThis study tested two ways to inject a cortisone medicine (triamcinolone acetonide) to treat genital lichen sclerosus, a skin condition causing itching, pain, and discomfort in women. Twenty women who did not improve with standard creams received injections either by a traditiona…
Phase: NA • Sponsor: Clinica Dermatologica Arbache ltda • Aim: Symptom relief
Last updated Jun 27, 2026 08:13 UTC
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New cream shows promise for vulvar itch relief
Symptom relief CompletedThis study tested a cream called MC2-25 to see if it can safely reduce itching in women with vulvar lichen sclerosus, a skin condition that causes discomfort. 33 women used either the active cream or a placebo for 12 weeks. The main goal was to measure how much the worst itching …
Phase: PHASE2 • Sponsor: MC2 Therapeutics • Aim: Symptom relief
Last updated Jun 27, 2026 07:54 UTC