Vulvar carcinoma

This early-stage study tests whether adding the HIV drug nelfinavir to standard chemotherapy (cisplatin) and radiation can safely treat advanced vulvar cancer that has spread and cannot be surgically removed. About 25 adults with stage II-IVA vulvar cancer will take part. The mai…

This study tests whether two drugs, pembrolizumab and lenvatinib, can shrink tumors in people with vulvar cancer that has come back, spread, or is too advanced for surgery or radiation. About 42 participants will receive the combination. The main goal is to see how many have thei…

This study tests a treatment called electrochemotherapy for women whose vulvar cancer has come back. It combines a chemotherapy drug (bleomycin) with electric pulses to help the drug enter cancer cells more effectively. The goal is to shrink tumors and avoid major surgery. Only 1…

This early-phase study tests a new radioactive drug, [177Lu]Lu-AKIR001, in 15 adults with advanced solid tumors (like thyroid, head and neck, cervical, vulvar, or lung cancer) that have stopped responding to standard treatments. The main goal is to check the drug's safety and sid…

This phase 2 trial tests whether cryocompression therapy, alone or combined with the drug cilostazol, can prevent peripheral neuropathy in people receiving paclitaxel for gynecologic cancers. Peripheral neuropathy causes numbness, pain, or tingling in the hands and feet and is a …

This trial tests a blended e-health program designed to help women with breast or gynecologic cancer cope with fear of their cancer returning or worsening. The program combines remote group sessions with online modules that teach skills to manage unhelpful thoughts and promote he…

This phase 2 trial tests whether a vaginal DHEA suppository can safely improve vaginal health in 25 women who had radiation for gynecologic, anal, or rectal cancer. Radiation often causes dryness, burning, and pain, similar to menopause. DHEA is a hormone replacement that may hel…

This observational registry is gathering data from 500 adults whose gynecologic cancer has returned after prior radiation therapy. Doctors are using reirradiation or other ablative strategies as part of standard care, and the registry will track how well these treatments control …

This study looks at whether regular groin ultrasound scans can safely replace surgery to check for cancer spread in women with early-stage vulvar cancer. About 30 women will be randomly assigned to either have groin surgery or get ultrasound checks every 2 months for a year. The …

This study will follow 200 patients with vulvovaginal cancer who received radiation therapy (with or without chemotherapy) to see how the disease returns and how their quality of life changes over time. Researchers will also look at certain biological markers. The goal is to gath…