New drug duo offers hope for hard-to-treat vulvar cancer
NCT ID NCT05903833
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether two drugs, pembrolizumab and lenvatinib, can shrink tumors in people with vulvar cancer that has come back, spread, or is too advanced for surgery or radiation. About 42 participants will receive the combination. The main goal is to see how many have their tumors shrink or disappear within 24 weeks.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Hochtaunus-Kliniken Bad Homburg
RECRUITINGBad Homburg, Germany
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KEM Kliniken Essen-Mitte
RECRUITINGEssen, Germany
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Klinikum Hanau GmbH
RECRUITINGHanau, Germany
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Klinikum der Universität München, LMU
RECRUITINGMünchen, Germany
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University Hospital
RECRUITINGTübingen, Germany
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University Hospital Hamburg
RECRUITINGHamburg, Germany
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Universitätsklinikum Augsburg
RECRUITINGAugsburg, Germany
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Universitätsklinikum Carl Gustav Carus Dresden
RECRUITINGDresden, Germany
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Universitätsklinikum Düsseldorf
RECRUITINGDüsseldorf, Germany
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Universitätsklinikum Essen
RECRUITINGEssen, Germany
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Universitätsklinikum Mannheim
RECRUITINGManheim, Germany
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Universitätsklinikum Münster
RECRUITINGMünster, Germany
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Universitätsmedizin Göttingen
RECRUITINGGöttingen, Germany
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Universitätsmedizin Mainz
RECRUITINGMainz, Germany
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ZAGO - Zentrum für ambulante gynäkologische Onkologie
NOT_YET_RECRUITINGKrefeld, Germany
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Two-Drug combo aims to shrink vulvar tumors before surgery
- New registry aims to learn from Real-World retreatment of gynecologic cancers
- Blood test and patient surveys aim to outsmart vulva cancer recurrence
- Could a single dye replace the standard two-step test for vulvar cancer spread?
- New combo therapy shows promise for Hard-to-Treat vulvar cancer
- Electric pulses + chemo: new hope for vulvar cancer?