Uterine cervix neoplasm

This study tests a new drug, LY4170156, designed to attack cancer cells with a specific marker (folate receptor alpha). It is for people with advanced solid tumors like ovarian, lung, or breast cancer that have not responded to other treatments. The trial has two parts: first fin…

This trial is testing whether adding the immunotherapy drug enlonstobart to standard chemotherapy and radiation can improve outcomes for people with locally advanced cervical cancer. Participants first receive enlonstobart with chemotherapy, then continue enlonstobart alongside c…

This phase II trial is testing whether a short course of radiation combined with the immunotherapy drug adebrelimab and a single platinum chemotherapy drug can eliminate all signs of cancer before surgery in women with locally advanced cervical cancer. Participants receive the co…

This study investigates a new treatment approach for locally advanced cervical cancer that combines carbon ion radiotherapy with immunotherapy (anti-PD-1) and chemotherapy. The goal is to see if this triple therapy improves how long patients live without their cancer progressing.…

This early-stage trial is testing a new drug called sigvotatug vedotin, alone or with other cancer medicines, in people with advanced solid tumors like lung, head and neck, and breast cancers. The study aims to find a safe dose and check for side effects. About 1,000 participants…

This phase 2 trial is testing a combination of two immunotherapy drugs (iparomlimab and tuvonralimab) plus standard chemotherapy before surgery in 103 women with locally advanced cervical cancer. The goal is to see if this approach can shrink tumors enough to allow less extensive…

This early-phase trial tests a new drug, UCB4594, in people with advanced solid tumors that haven't responded to standard treatments. The drug is a monoclonal antibody that targets a protein called HLA-G on cancer cells, potentially helping the immune system attack them. The stud…

This phase II trial is testing whether the immunotherapy drug dostarlimab, alone or combined with bevacizumab, can control recurrent gynecological clear cell carcinoma better than standard chemotherapy. About 198 women with this rare cancer type will be randomly assigned to one o…

This study evaluates a rapid test called Methylscape that measures DNA methylation patterns in body fluids like blood, urine, or saliva. The goal is to see if it can detect a cancer signal and even predict where the cancer started, using a single sample. Researchers will compare …

This study is testing a new, low-cost screening tool for cervical cancer that uses artificial intelligence to analyze digital images of the cervix. It does not require a lab and can be used at the point of care. The goal is to see if this AI tool can accurately detect precancerou…

This study follows 80 cervical cancer patients who receive brachytherapy (internal radiation) to see if they develop post-traumatic stress disorder (PTSD). Participants fill out questionnaires about PTSD, anxiety, depression, quality of life, and sexual health over 5 years. The g…

This study looks at whether an interactive video program, combined with help from a community health worker, can increase cervical cancer screening among African American women who are overdue for a test. About 288 women will take part, completing two phone surveys and having the…

This study compares three different surgical methods for removing abnormal cervical tissue (conization) to see which one causes the least heat-related damage. The goal is to improve the accuracy of lab analysis after surgery. 150 women needing this procedure will take part, and p…

This study looks at MRI scans from 120 women with advanced cervical cancer to see if a computer model can predict how well their tumors respond to standard chemotherapy and radiation. The goal is to identify women who might need different or stronger treatments early on. Research…