Treatment-refractory schizophrenia
MONDO:0005414Schizophrenia which does not respond to commonly used treatments.
Also known as: TRS, refractory schizophrenia, treatment-refractory schizophrenia
93 clinical trials for this condition and its sub-types.
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Brain pacemaker tested for untreatable schizophrenia
Disease control TerminatedThis pilot study tested deep brain stimulation (DBS) in 15 people with treatment-resistant schizophrenia who still had severe hallucinations despite medication. The device was placed in a brain area linked to schizophrenia to try to calm symptoms. The study was terminated early, …
Phase: NA • Sponsor: Johns Hopkins University • Aim: Disease control
Last updated Jun 27, 2026 12:33 UTC
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Brain training for psychosis: a small step toward better school performance
Symptom relief TerminatedThis study looked at whether adding cognitive remediation therapy (a type of brain training) to supported education (help returning to school) improves academic functioning in young adults with psychotic disorders. Only 9 people enrolled before the study was stopped early. The go…
Phase: NA • Sponsor: Centre de Recherche de l'Institut Universitaire en Santé Mentale de Québec • Aim: Symptom relief
Last updated Jun 27, 2026 11:03 UTC
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Tiny study probes why clozapine beats other schizophrenia drugs
Knowledge-focused TerminatedThis study aimed to compare the effects of clozapine versus other antipsychotic medications on inflammation in people with treatment-resistant schizophrenia. Researchers measured inflammatory markers like interleukin-6 in a small group of participants. The study was terminated ea…
Phase: PHASE4 • Sponsor: Ohio State University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:07 UTC