Tourette syndrome

This Phase 3 study tested whether ecopipam can safely maintain tic control in 216 people with Tourette's disorder, ages 6 and up. Participants first received open-label ecopipam, then those who responded were randomly switched to placebo or continued ecopipam to see if benefits l…

This completed trial in Xishui, China, tested a community-based program for 3,571 adults aged 35 and older who were at high risk for COPD and had mental health symptoms. The program included lung function tests, digital mental health support, smoking cessation help, and health ed…

This study tested whether a team-based care model can help people with both opioid use disorder and mental health issues like depression or anxiety. 254 adults in primary care received either full collaborative care for both conditions or just mental health support. The goal was …

This completed study tested whether a Mediterranean diet could improve metabolic syndrome markers in 30 hospitalized adults with psychiatric conditions. Participants followed either a Mediterranean diet or a standard hospital diet for 8 weeks, then switched. Researchers measured …

This trial tests whether rhythmic electrical pulses delivered to the wrist (median nerve stimulation) can reduce tics and the urge to tic in people with Tourette syndrome or chronic tic disorder. Participants wear a portable device for 15 minutes at a time over four weeks. The st…

This study tested a counseling program called Youth Friendship Bench SA for young women aged 18-25 in South Africa who had symptoms of depression, anxiety, or stress. The program included individual and group counseling sessions, plus optional text reminders. The goal was to see …

This study tested a drug called ecopipam in 40 children aged 7 to 17 with Tourette's syndrome. The goal was to see if it could reduce the frequency and severity of their motor and vocal tics. The drug works by blocking certain dopamine receptors in the brain. The main measure was…

This study tested whether a 4-week program using active video games (exergames) on the Nintendo Switch could help adults with mental illness feel better and stay motivated. Twelve participants were split into two groups: one played exergames, the other continued their usual routi…

This small study tested whether Epidiolex (a prescription CBD oil) can safely reduce symptoms of obsessive-compulsive disorder, hair-pulling, Tourette syndrome, and hoarding. Four adults took the drug for two weeks. The goal was to see if symptoms improved and if the drug was wel…

This study tested a 10-week peer support program called 'Paths to everyday life' for adults with mental health difficulties. Participants were randomly assigned to either the peer support group plus usual services, or usual services alone. The goal was to see if the program impro…

This study tested whether a probiotic supplement called Lactobacillus plantarum PS128 can improve tic symptoms and quality of life in children with Tourette's syndrome. 121 children aged 4-18 took part. The main goal was to see if PS128 reduces tic severity and related emotional …

This study tested a 10-session dog-assisted therapy program for 60 adults with severe mental illness. The goal was to see if spending time with trained therapy dogs could help participants build positive mental health behaviors like communication and socialization. Researchers me…

This study tested a 6-week supervised physical activity program for university students dealing with mild-to-moderate mental health issues like stress, anxiety, or feeling isolated. Seventeen students took part in group exercise sessions including walking, aerobics, and strength …

This completed study from the National Institute of Neurological Disorders and Stroke aimed to better understand how the brain controls movement and what goes wrong in movement disorders like Parkinson's disease, Tourette's syndrome, and dystonia. Over 1,200 adults—both patients …

This study tested whether a 10-week recovery program, co-led by a peer with mental illness and a professional, is feasible for people with mental illness in Taiwan. Twenty participants completed the program, which focused on recovery concepts, strengths, and goal setting. Researc…

This study looked at 132 teenagers with Tourette syndrome to understand how their brains and thinking skills change during adolescence. Researchers used brain scans (MRI), magnetic pulses (TMS), and computer tests to measure brain connections, control, and decision-making. The go…

This study tested a web application called PRATICAdr 2.0, designed to help healthcare workers on sick leave due to common mental disorders like depression or anxiety return to work. The app helps coordinators track progress and improve communication. Researchers compared workers …

This study tested whether artificial intelligence (AI) can realistically simulate conversations between a therapist and a person with a mental health problem. Researchers used 520 simulated sessions to see if the AI could follow proper therapy techniques. The goal is to use these…

This study looked at brain activity in the frontal cortex of 14 people with Tourette syndrome using a 24-hour portable EEG. Participants pressed a button each time they had a tic, so researchers could compare brain signals with and without tics. The goal was to identify which bra…

This study looked at how thinking skills and brain activity differ in people who self-harm compared to those who don't. Researchers interviewed 316 adults and gave them thinking tests, with some also having brain scans. The goal was to better understand self-harm to help create m…

This study tested a program called Recovery Bridge, where trained peer specialists (people with lived experience of mental illness) helped veterans leaving a psychiatric hospital connect to outpatient care and community life. Fifteen veterans took part to see if the program was f…

This completed study looked at 400 people with both heart disease and a mental health condition (like depression or anxiety). Researchers used questionnaires, blood tests, and imaging to find shared risk factors and biological markers. The goal was to better understand how these …

This study tested whether an anti-stigma training program for healthcare providers improves attitudes toward people with mental illness or substance use problems. About 485 staff and clients from six health centers took part, with three centers receiving the training and three no…

This completed study followed 509 children aged 3 to 18 who were taking risperidone or aripiprazole for conditions like schizophrenia or bipolar disorder. Researchers measured weight changes over up to 50 months to understand long-term risks. The goal was to provide better safety…

This study looked at how often insomnia occurs in people hospitalized for psychiatric conditions. Researchers checked 427 patients at 11 hospitals in Switzerland and Germany. They also explored whether age, gender, or type of disorder made insomnia more likely.

This completed study tested whether a short, non-invasive brain stimulation technique called theta burst stimulation (iTBS) could improve brain circuits involved in tic control. Sixteen people with Tourette syndrome, aged 10 to 21, received either real or sham stimulation. The go…

This study tested an 8-month program called 'Meaningful Activities and Recovery' (MA&R) for people with mental illness. The program helps people take part in activities that matter to them. 139 adults took part to see if the program improves activity engagement, recovery, and qua…

This study tested a program called iCOT to improve how occupational therapy interns communicate with patients in mental health settings. The program included online training and feedback from patients, supervisors, and experts. Researchers compared interns who received iCOT to da…

This study tested whether a systematic phone call from a medical student, supervised by a general practitioner, could reduce hospitalizations in patients with chronic heart or mental health conditions during the COVID-19 lockdown in France. Over 22,000 patients aged 70 and older …

This completed study looked at how people with Tourette syndrome perceive their own actions compared to external forces. Researchers measured a phenomenon called sensory attenuation, which reflects how the brain integrates sensory feedback with motor commands. The study involved …

This study tested different parts of a family navigation program to see which ones work best for helping low-income and minority families get mental health services for their children. 312 children aged 3-12 who showed signs of behavioral health concerns took part. The goal was t…

This study used artificial intelligence to predict how engaged people would be in online therapy and how much their symptoms would improve. Researchers analyzed data from over 6,600 adults who took part in a digital psychotherapy program. The goal was to create fair and accurate …

This study created and tested a mobile app called VetEd for student veterans dealing with mental health issues like depression, PTSD, or anxiety. The goal was to help them manage academics, mental health, and find resources. Researchers worked with 13 veterans to see if the app w…

This completed study looked at 224 adults who already had at least one psychiatric condition to see how many also had undiagnosed ADHD. Researchers measured how often ADHD was missed and tracked quality of life in those diagnosed. The goal is to highlight the need for better dete…

This study tested a wrist-worn device called the Personal KinetiGraph (PKG) to see if it can accurately measure movement problems in people with Parkinson's disease. Nineteen participants wore the device while researchers compared its readings to standard clinical tests and video…

This study aimed to create and test a new scale called TD-STIGMA to measure stigma and discrimination in children and young adults with chronic tic disorders, including Tourette syndrome. Researchers worked with 43 participants, including people with tics and their caregivers, to…

This study used brain scans and behavioral tests to explore why people with Tourette syndrome often act impulsively. Researchers compared 80 patients (40 on medication, 40 not) with 40 healthy volunteers. The goal was to map brain connections linked to impulsivity, which could he…