Symptomatic heart failure

This study follows up to 300 people with advanced heart failure in South Korea who receive a HeartMate 3, a mechanical pump that helps the heart circulate blood. Researchers will track how long patients survive without a debilitating stroke or the need for a pump replacement, as …

This study tests whether hearts from donors with hepatitis C can be safely transplanted into people without the virus. Twenty adults with end-stage heart failure on the transplant waiting list will receive these hearts and take antiviral medication to prevent infection. The goal …

This study tested a device called the DuoCor Ventricular Assist System, an implantable heart pump for people with advanced heart failure. Eight adult patients who needed support for both sides of the heart received the pump. The main goal was to see if patients survived for 3 mon…

This study followed 220 advanced heart failure patients who received a CH-VAD heart pump to see if adding aspirin to the standard blood thinner warfarin changed their risk of serious bleeding or clotting events. The main goal was to compare survival without stroke, pump clots, ma…

This study tested a new way to manage heart failure using a small heart monitor (Reveal LINQ) and a special algorithm. The goal was to see if this approach could safely guide treatment and improve outcomes for people with moderate heart failure. 826 participants with NYHA class I…

This study tested whether a special clinic (GDMT Clinic) helps heart failure patients get the right medications compared to usual care. About 300 adults with heart failure took part over 12 weeks. The clinic aimed to improve medication use, health status, and heart function.

This completed study tested whether adding sildenafil to dapagliflozin helps heart failure patients who also have high blood pressure in their lungs. 100 participants received either dapagliflozin alone or both drugs. Researchers measured changes in heart pumping strength and lun…

This study tested a device called the Cordella™ Heart Failure System in 15 people with advanced heart failure. The system includes a small sensor implanted in the lung artery that measures pressure, sending data to doctors remotely. The goal was to see if it is safe and accurate,…

This study tested whether a special type of heart MRI, called T1 mapping, can accurately diagnose cardiac amyloidosis—a condition where abnormal proteins build up in the heart muscle. Researchers studied 112 older adults with heart failure and thickened heart walls. They compared…

This study tested a modified pacemaker in 34 people with heart failure (NYHA class II or III). The device delivers special pacing signals to reduce overactive sympathetic nerve activity, which can strain the heart. Researchers measured changes in arterial elastance, a sign of rel…

This study tested a program called ADAPT HF, which uses a lay coach or self-guided materials to help Black adults with advanced heart failure manage pain. Ten participants completed weekly sessions covering pain education, relaxation, social support, and coping. The goal was to s…

This study looks at people with end-stage heart failure who have a mechanical heart pump (LVAD). It checks whether the pump's flow rate, adjusted for body size, is linked to liver and kidney function and the chance of being readmitted to the hospital. The goal is to see if this m…

This study looked at how common cardiac cachexia (unintentional weight loss) is in people with advanced heart failure and how it affects their outcomes. Researchers followed about 200 patients for one year to compare survival and hospitalizations between those with and without th…

This study tested a new way for doctors to discuss CPR with older, seriously ill patients and their families. Instead of the usual conversation, doctors followed a step-by-step guide that focused on the patient's values and explained why CPR might not help. The goal was to see if…

This completed observational study looked at how often heart failure patients in a French nationwide remote monitoring program were prescribed SGLT2 inhibitors between 2021 and 2024. Researchers analyzed data from over 13,600 adults to see how prescription rates changed over time…

This study looked at 200 heart transplant patients to see if the time of day the donor heart was removed affects how well the patient does. Researchers compared hearts taken during the body's rest phase (midnight to noon) versus the active phase (noon to midnight). They tracked s…

This study analyzed data from nearly 5,000 Japanese patients with chronic heart failure who started taking vericiguat as part of their regular care. Researchers tracked outcomes like hospital stays and deaths over one year to see how the drug performs in everyday practice. The go…

This study looked at how well a device called the Organ Care System (OCS) works for preserving donor hearts before transplantation. The OCS keeps the heart in a near-natural, beating state instead of on ice. Researchers followed 93 heart transplant recipients for 12 months to see…