Subcutaneous tissue disorder

This study tests whether adding hyaluronic acid gel to standard deep cleaning (scaling and root planing) improves gum healing in people with both diabetes and advanced gum disease. Twenty-three participants will receive the standard cleaning on all teeth, and then two gum pockets…

This Phase 3 trial tests garetosmab, an antibody that blocks activin A, in 18 children and teens with fibrodysplasia ossificans progressiva (FOP), a rare disease where muscle and tissue turn into bone. The study will check safety, side effects, and whether the drug reduces new ab…

This Phase 3 trial tests an oral drug called KP-001 in 150 people aged 2 and older with venous malformations, lymphatic malformations, or KTS/CLOVES syndrome. Participants receive either KP-001 or a placebo for 24 weeks, then everyone gets the drug for another 28 weeks. The goal …

This study tests whether a mobile app using artificial intelligence can help frontline health workers in sub-Saharan Africa better diagnose skin-related neglected tropical diseases, like leprosy and scabies. Researchers will collect images from dermatologists to train the AI, the…

This study tests whether adding a personalized anti-inflammatory diet to standard physical therapy (compression, massage, and exercise) reduces leg swelling and improves quality of life in women with lipedema. 75 women aged 18-65 with stage I-III lipedema will be randomly assigne…

This study will compare two types of supervised cycling exercise (high-intensity intervals or moderate continuous cycling) combined with compression therapy against compression plus a home walking program in 69 women with lipedema. The goal is to see which approach best reduces l…

This study tests whether adding shockwave therapy to standard care (like compression and massage) can reduce pain and swelling in women with lipedema. Fifty women aged 18-65 with early-stage lipedema will be randomly assigned to receive either standard care alone or standard care…

This study investigates whether a natural molecule called Maresin-1, which helps reduce inflammation, is linked to lipedema—a chronic condition causing painful fat buildup in women. Researchers will measure Maresin-1 levels in the blood of women with lipedema, women with obesity …

This study looks at whether vein problems are linked to pain, swelling, and daily function in women with lipedema. Researchers will use ultrasound to check leg veins and ask participants about their symptoms. The goal is to better understand how these conditions interact, which c…

This study will compare women with knee osteoarthritis who also have lipedema (a fat tissue disorder) to those without lipedema. Researchers will use ultrasound to measure knee cartilage thickness and questionnaires to assess pain and daily function. The goal is to understand if …

This study will test a specially trained AI model (like ChatGPT) to see if it can help doctors correctly diagnose and recommend treatments for lymphedema, lipedema, and venous insufficiency. Researchers will compare the AI's suggestions to current medical guidelines. The goal is …

This observational registry will follow over 6,000 people who have been prescribed the Jewel P-WCD, a wearable defibrillator that can detect and treat dangerous heart rhythms. The goal is to confirm the device continues to work safely and effectively in everyday life. No new trea…