Subcutaneous tissue disorder

This study tested whether shear wave elastography, a special ultrasound technique that measures tissue stiffness, can help diagnose lipedema—a chronic condition causing painful fat buildup in the legs, mostly in women. Researchers compared tissue stiffness in 95 women (lipedema p…

This study compares two exercise approaches—supervised Pilates and telerehabilitation (remote Pilates)—to see which better improves exercise capacity and quality of life in women with lipedema. Participants will also follow a low-carb, high-fat diet for 12 weeks. The goal is to f…

Lipedema is a painful fat condition in women's legs, often treated with liposuction. Recovery can involve swelling, pain, and stiffness. This study tested whether adding Endermologie—a gentle suction-and-rolling massage—to standard physiotherapy helps 88 women heal faster. The re…

This study looked at whether a 7-month low-carb, high-fat (ketogenic) diet could improve symptoms and quality of life in 121 women with lipedema, a chronic fat tissue disorder causing painful leg swelling. Participants followed the diet and were monitored for changes in leg size,…

This study tested whether ozone therapy can reduce pain and tissue thickness in women with lipedema, a painful fat disorder. 45 women received either local or systemic ozone treatments. The goal was to see if ozone's anti-inflammatory effects could improve symptoms and quality of…

This completed study created a biorepository of blood and tissue samples from 60 women with and without lipedema. The goal was to find molecular markers that can distinguish lipedema from obesity, which is often misdiagnosed. Researchers measured immune markers and physical funct…

This completed study looked at how lipedema impacts exercise habits and physical activity in women. Researchers compared 119 women with lipedema to healthy women of similar age and background. They used questionnaires to measure activity levels, exercise stages, and perceived bar…

This study looked at how fat cells grow in women with lipedema, a condition that causes painful fat buildup in the legs. Seventeen women drank heavy water so researchers could track new fat cell formation. The goal was to better understand what makes lipedema different from regul…

This study looked at 30 women—half with lipedema and half without—to understand how the condition affects muscle strength, endurance, leg function, aerobic fitness, pain sensitivity, and swelling. Researchers used simple tests like walking and sitting to measure differences. The …

This completed study created a French national registry for people with rare overgrowth syndromes caused by PIK3CA gene mutations. Researchers collected medical and genetic information from 28 patients to better understand these conditions and estimate how many people are affecte…

This study looked at 140 women to compare metabolic risk markers—like insulin resistance and cholesterol ratios—between those with lipedema and those with obesity. Researchers used existing blood test results to calculate these markers without any new treatments or interventions.…

This completed study looked at 60 women with lipedema and healthy controls to understand how central sensitization (a heightened pain response in the nervous system) relates to pain and emotional factors. Researchers measured pain sensitivity, anxiety, depression, and pain catast…

This study looked at whether whole genome sequencing (a complete read of a person's DNA) can help diagnose leukodystrophies, a group of rare brain diseases that are hard to identify. Researchers enrolled 236 children with white matter abnormalities on brain scans but no known gen…