Streptococcal toxic-shock syndrome

This study tested a single dose of the antibiotic oritavancin in 41 children under 18 with suspected or confirmed bacterial infections. The goal was to find the right dose and check for safety and side effects. It was an early-stage trial, so it focused on how the drug moves thro…

This study looked at whether giving hospital-level care to acutely ill adults in their own homes in rural areas works well. 160 people with various conditions like infections, heart failure, or COPD took part. The goal was to see if this approach could lower costs and help patien…

This study tested whether giving intravenous immunoglobulin (IVIG) to children with toxic shock syndrome is practical and might help. Toxic shock is a rare but life-threatening reaction to bacterial toxins. The trial enrolled 30 children in intensive care, giving them either IVIG…

This study looked at how well a new, quick finger-prick test (LumiraDx CRP) measures CRP levels compared to a standard lab test. CRP is a marker of infection, inflammation, or tissue injury. 79 adults with symptoms of these conditions took part. The goal was to see if the new tes…

This early study tested whether a special PET scan using a radioactive form of vitamin B9 (11C-PABA) can help doctors see infections deep inside the body. Researchers scanned 13 healthy people and patients with known or suspected infections. The goal was to see if this method can…

This study tested whether a probiotic called Bifidobacterium breve PRL2020 could reduce stomach issues like diarrhea in 121 children aged 3-12 who were taking amoxicillin antibiotics. The children took the probiotic alongside their antibiotic treatment. The goal was to see if it …

This study looked at 335 adults hospitalized with bacterial infections to see if taking NSAIDs (like ibuprofen) before admission made their infections more severe. Researchers compared those with complicated infections (abscesses, needing surgery) to those with simpler infections…

This study aimed to find the best dose of the antibiotic ceftazidime for critically ill children with severe burns. Researchers took blood samples from 3 children to measure how the drug moves through the body. The goal was to learn how to personalize dosing to improve treatment …

This early-phase study tested a single dose of the antibiotic omadacycline (Nuzyra) in 23 children aged 8 to 17 who were hospitalized with bacterial infections. Researchers measured how the drug moved through the body and checked for side effects. The goal was to gather safety an…

This study tested a new imaging technique using a radioactive tracer called 11C-trimethoprim to see how it spreads in the bodies of 16 adults with suspected bacterial infections. Participants had PET/CT scans to track the tracer over time. The goal was to learn how the tracer beh…

This study tested whether giving a personalized dose of the antibiotic vancomycin to critically ill children in the ICU leads to better results than the standard approach. Researchers enrolled 314 children and compared how many reached the target drug level in their blood. The go…

This study looked at 156 critically ill patients to find out what factors help achieve the right levels of beta-lactam antibiotics in the blood. Researchers collected clinical data and used therapeutic drug monitoring to see which patients reached target concentrations. The goal …

This study tested special wearable pumps (elastomeric pumps) to give antibiotics through a drip to hospital patients. Nine adults with bacterial infections took part to see if the pumps are safe, easy to use, and could save time and money compared to traditional methods. The goal…